Clinical Diagnosis
Immunoglobulins (Igs) are proteins produced in response to invasion by foreign pathogens in the body. In humans, five distinct classes have been identified, i.e. IgG, IgM, IgA, IgE, and IgD. In recent years, the research of non-IgG antibodies has attracted much attention due to their distinct advantages in immunotherapy. Here, Creative Biolabs gives a brief introduction to the diagnostic applications of non-IgG antibody isotypes.
Fig.1 Illustration of the different classes of immunoglobulins IgA, IgG, IgD, IgE, IgM.1
IgA is the second most abundant antibody in human serum, existing in both monomeric and dimeric forms. It plays an important role in the primary defense against infections, thereby highlighting its potential in disease diagnosis. Xiao et al. (2017) reported high levels of lipoprotein Z (LppZ)-specific IgA in tuberculosis (TB) and latent tuberculosis infection (LTBI). IgA levels may serve as a complementary marker for detecting TB and LTBI infections, as well as for monitoring disease treatment.
IgM is the largest antibody, and it is the first antibody to appear in response to initial exposure to an antigen. As a result, the detection of specific IgM against a pathogen in the serum of patients is often used to help disease diagnosis based on ELISA methods. For instance, some virus infection could be diagnosed through the ELISA determination of virus-specific IgG and IgM antibodies. Besides, as it is synthesized by the fetus, IgM can’t cross the placenta. Therefore, the presence of IgM in the fetus or newborn indicates intrauterine infection and IgM detections are useful for the diagnosis of congenital infections such as Toxoplasmosis, syphilis, rubella, cytomegalovirus infection, and human immunodeficiency viruses (HIV) infection.
The main function of IgE is its immune defense against different parasites. Besides, it has an essential role in allergic diseases and is found to be elevated in various autoimmune diseases. It is a golden role to detect IgE antibodies by a serological method or by its companion in vivo skin test assay, which simply identifies whether a state of sensitization (IgE antibody positivity) exists in a patient to a particular allergenic specificity. Besides, specific applications of IgE antibodies testing include the diagnosis of different allergic diseases, including aeroallergen inhalation-induced disease, drug allergy, food allergy, etc.
IgY is a kind of non-mammalian antibody isolated from chicken egg yolk, which is commonly used in the dietary supplement and scientific research. Its non-invasive obtaining method and high specificity make IgY antibody a potential candidate in clinical diagnostic and therapeutic applications, particularly in viral and bacterial infections.
Besides their potential in disease diagnosis, the use of non-IgG antibodies as therapeutics has become one of the most innovative areas. As an expert in therapeutic antibody research, Creative Biolabs now uses our high-end technologies and rich experience to develop and engineer non-IgG antibodies products with optimized characteristics and performance, meanwhile, providing high-quality custom non-IgG antibody services.
For more detailed information, please feel free to contact us or directly sent us an inquiry.
References
- Maverakis, Emanual, et al. "Glycans in the immune system and the altered glycan theory of autoimmunity: a critical review." Journal of autoimmunity 57 (2015): 1-13. Distributed under CC BY 4.0, without modification.
- Xiao, J.N.; et al. Determination of Lipoprotein Z-Specific IgA in Tuberculosis and Latent Tuberculosis Infection. Frontiers in Cellular and Infection Microbiology. 2017, 7: 495. Distributed under CC BY 4.0, mentioned by summarizing some parts of the article.
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For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.