Upcoming Therapeutic Options for IgA Nephropathy
IgA Nephropathy (IgAN) is a global leading cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD). It is an autoimmune disorder characterized by the deposition of IgA antibodies in the kidney, leading to inflammation and gradual loss of kidney functions.
>> Learn MoreThe Changing Treatment Landscape of IgA Nephropathy Over the Past Half Century
The IgA nephropathy was first described by French scholar Jean Berger in 1968, marking the beginning of scientific exploration in this field. Today, after more than half a century of arduous exploration, significant progress has been made in understanding both the pathogenesis and treatment methods of IgA nephropathy.
>> Learn MoreCurrent Treatment Options for IgA Nephropathy
IgA Nephropathy, also known as Berger's disease, is a kidney disorder that results from deposits of the immunoglobulin A (IgA) in the glomeruli within the kidneys. This condition can lead to local inflammation, eventually impairing the kidneys' ability to filter wastes from the blood effectively.
>> Learn MoreThe Coordinated Role of IgG and IgM in Coating Gut Bacteria in the Absence of IgA
The gut serves as the largest interface for interaction between our body's indigenous microbes and the host immune system. Maintaining a distinct separation between microbes and adjacent tissues is crucial for sustaining a non-inflammatory homeostasis state in the human body.
>> Learn MoreNasal IgA Antibody Drops - A Promising Defense Against SARS-CoV-2 and Future Variants
The ongoing spread of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) poses significant challenges to public health worldwide. The emergence of mutations and variants of concern (VOCs) has been a direct consequence of the virus's evolution under the selective pressure of antibody responses from recovered and/or vaccinated individuals.
>> Learn MoreIgA Antibody Drug Ejects Problematic Proteins from Cancer Cells
Antibody-based therapies have marked a significant advancement in cancer treatment, offering targeted approaches to combat malignancies. Traditionally, these therapies have focused on extracellular proteins associated with cancer cells, leaving intracellular oncoproteins, which play a pivotal role in cancer progression, largely unaddressed.
>> Learn MoreThe Novel Role of IgA Antibodies in the Fight Against Malaria
IgA, or immunoglobulin A antibody is well documented for its crucial role in defending against mucosally acquired pathogens. However, its specific function in immune responses to non-mucosal pathogens such as Plasmodium falciparum, the causative agent of the deadly malaria, remains unclear despite IgA being the second-most abundant antibody class in the bloodstream.
>> Learn MoreThe Immune Landscape of IgA Induction in the Gut
Secretory Immunoglobin A (SIgA), the primary form of immunoglobulin A (IgA) in the mucosal immune system, plays a vital role, not only in fighting infections but also in protecting mucosal surfaces from toxins and environmental factors. SIgA's role is essential for balancing the coexistence of the immune system with microbial communities within the body.
>> Learn MoreDiscovery of Anti-Mesangial Autoantibodies Redefines the Pathogenesis of IgA Nephropathy
IgA Nephropathy (IgAN) is the most common primary glomerulonephritis, characterized by the accumulation of Immunoglobulin A (IgA) in the glomeruli - the tufts of capillaries filtering blood in the kidneys. In the advanced stages of the disease, IgA deposition within the glomeruli compromises kidney function, leading to kidney failure in 30% to 40% of cases.
>> Learn MoreDifference Between Protein A/G/L
Affinity chromatography is a chromatographic technique that uses the specific affinity between biomolecules for separation. Specifically, affinity chromatography involves immobilizing a ligand on an inert carrier, and the target protein in the mixture is specifically bound to the ligand and thus captured, while the extraneous impurity components are washed off with the mobile phase...
>> Learn MoreNon-IgG Antibody Drug Conjugate
Non-IgG Antibody Drug Conjugate (non-IgG ADC) is a novel drug combination that combines antibodies specifically targeting specific proteins or cell surface markers with potent cytotoxic drugs, thus providing highly targeted and effective treatments for certain cancers. Traditionally, ADCs have been designed using immunoglobulin G (IgG) antibodies...
>> Learn MoreAllergen Immunotherapy (AIT)
Allergen immunotherapy (AIT) is the only effective treatment for allergic diseases that induces immune tolerance while reducing symptoms in patients with asthma and allergic rhinitis (AR). The principle of this therapy is to reduce the symptoms of allergic diseases by inducing tolerance to allergens...
>> Learn MoreBiologics for the Treatment of Allergic Diseases
New research into allergic diseases is ongoing, especially the development and application of new biological agents. A researcher at the American College of Allergy, Asthma and Immunology (ACAAI), mentioned that traditional asthma treatments are ineffective for some people whose asthma cannot be controlled...
>> Learn MoreWhat Factors Affect the Production and Secretion of IgE
Immunoglobulin E (IgE) antibodies are synthesized and secreted into the blood and tissues by B cells, and the regulation of their production and secretion is mediated by T cells. When specific allergens, such as pollen, mold, and dust mites, enter the body, the body's immune system stimulates T cells to produce and secrete the cytokines IL-4 and IL-13...
>> Learn MoreB-1 Cells that Produce IgM Antibodies
B cells that produce IgM antibodies play a significant role in immune responses. These cells include B-1 cells and B-2 cells, which produce different types of IgM antibodies and function in different mechanisms with target organs...
>> Learn MoreB-2 Cells that Produce IgM Antibodies
Cells are important immune cells that produce antibodies. Based on their different origins and functions, B cells can be divided into two types: B-1 cells and B-2 cells. B-2 cells are classical B lymphocytes that mainly exist in peripheral blood and lymphoid organs...
>> Learn MoreClinical Implications of Non-IgG Antibodies in Transplant Rejection
Organ transplantation provides an avenue for patients with end-stage organ failure to regain health and improve their quality of life. However, transplant rejection, characterized by the recipient's immune system attack on the donor organ remains a constant threat. Antibodies produced by the recipient's immune system are key players in this process...
>> Learn MoreNon-IgG in Autoimmune Diseases: Pathogenic Contributors or Protective Allies?
Autoimmune diseases are conditions in which the body's immune system mistakenly attacks its own cells and organs. To understand autoimmunity, it is vital to understand the role of antibodies. Usually, antibodies are proteins produced by the body to combat invaders such as viruses and bacteria. But, in autoimmunity...
>> Learn MoreThe Role of IgM Antibodies in Pathology
Antibodies, also known as immunoglobulins, are crucial proteins produced by the immune system. They play a vital role in combating pathogens. When it comes to pathology, IgM antibodies are significant in disease conditions like infections, autoimmunity, and tumors...
>> Learn MoreIgA Nephropathy - An Underestimated Kidney Disease
IgA Nephropathy, also known as Berger's Disease, is perhaps one of the most underestimated chronic kidney diseases. Characterized by the buildup of a specific antibody – Immunoglobulin A (IgA) – within the kidneys, this condition often goes unnoticed until it has advanced significantly...
>> Learn MoreIgM Antibodies for Breast Cancer Diagnosis
Breast cancer is a prevalent malignant tumor among women, and early detection plays a pivotal role in treatment and outlook. Presently, mammography serves as the primary screening technique...
>> Learn MoreT Cell Dependent IgA Class Switching
Immunoglobulin A (IgA) is a class of antibodies that play a major role in the immune function of mucous membranes. This class of antibodies is primarily produced in the gut, the largest immune organ in the body...
>> Learn MoreT Cell Independent IgA Class Switching
Immunoglobulin A (IgA) is a type of antibody that plays an essential role in the immune function of mucous membranes. The production of IgA involves a process known as class-switch recombination (CSR)...
>> Learn MoreThe Crucial Role of IgA in Gut Health
The human body and the gut microbiota share a symbiotic relationship, together creating a complete ecosystem within our intestines...
>> Learn MoreGroundbreaking Cancer Research - Novel IgE Antibody Shows Promise
Currently, all antibodies approved for the treatment of cancer belong to the IgG class. In this context, the emergence of IgE antibodies offers exciting prospects...
>> Learn MoreInvolvement of Nitric Oxide in IgA Synthesis
Nitric oxide (NO) is a free radical molecule expressed in some dendritic cells (DCs) and related cells in the intestine and involved in intestinal immunoglobulin A (IgA) synthesis...
>> Learn MoreMechanism of IgM Polymerization
Immunoglobulins play a vital role in our immune system, where their main job is to identify and neutralize foreign substances such as bacteria and viruses...
>> Learn MoreRole of Dendritic Cells in Intestinal IgA Production
Dendritic cells (DCs) play an important role in the gut as a specialized class of antigen-presenting cells with the dual function of inducing self-antigen tolerance and non-self-antigen immunity...
>> Learn MoreThe Glycobiology of SIgA - Microbiota Interactions
In the field of biology, the study of microbial-host interactions is a challenging and innovative task. One such area under investigation is the glycobiology of microbiota interactions...
>> Learn MoreIgE and miR-486A-5p: Potential Therapeutic Targets for Cardiac Fibrosis
Cardiac fibrosis is an integral part of many heart diseases. Characterized by an excessive deposition of the extracellular matrix (ECM) within cardiac interstitial spaces, it exacerbates the passive stiffness of the myocardium leading to progressive heart dysfunction...
>> Learn MoreMolecular Mechanism of IgM Recognition by FcμR
Immunoglobulin M (IgM) is a crucial player in the early phases of our immune response and happens to be one of five immunoglobulins found in our bodies...
>> Learn MoreThe Evolutionary Mechanisms of Hijacking IgM in Plasmodium falciparum
Malaria remains a significant public health issue worldwide. According to the World Health Organization, around 241 million people contracted malaria globally in 2020, resulting in approximately 627,000 deaths...
>> Learn MoreThe Mechanisms and Implications of IgM-mediated Pseudoallergy for Drug Delivery
Pseudoallergy refers to hypersensitivity reactions that resemble allergic reactions but are not mediated by IgE antibodies. Instead, they involve activation of the complement system, especially via IgM antibodies...
>> Learn MoreAn mRNA-based Expression of IgA Monoclonal Antibodies to Prevent Bacterial Infections
A pioneering study recently published in the Cell Reports Medicine, has demonstrated a groundbreaking approach to fighting bacterial infections...
>> Learn MoreDiscovery of Fish IgM Structure Sheds Light on Polymeric Antibody Evolution
Antibodies, protective proteins produced by the immune system, play a critical role in the identification and elimination of unwanted substances or antigens within organisms...
>> Learn MoreThe Beneficial Role of IgE in Host Defense against Bee Venom
While allergic reactions are often associated with discomfort and hassle, researchers from Stanford University have found that they might not be as unnecessary as perceived in the past...
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