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Difference Between Protein A/G/L

Affinity chromatography is a chromatographic technique that uses the specific affinity between biomolecules for separation. Specifically, affinity chromatography involves immobilizing a ligand on an inert carrier, and the target protein in the mixture is specifically bound to the ligand and thus captured, while the extraneous impurity components are washed off with the mobile phase...

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Non-IgG Antibody Drug Conjugate

Non-IgG Antibody Drug Conjugate (non-IgG ADC) is a novel drug combination that combines antibodies specifically targeting specific proteins or cell surface markers with potent cytotoxic drugs, thus providing highly targeted and effective treatments for certain cancers. Traditionally, ADCs have been designed using immunoglobulin G (IgG) antibodies...

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Allergen Immunotherapy (AIT)

Allergen immunotherapy (AIT) is the only effective treatment for allergic diseases that induces immune tolerance while reducing symptoms in patients with asthma and allergic rhinitis (AR). The principle of this therapy is to reduce the symptoms of allergic diseases by inducing tolerance to allergens...

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Biologics for the Treatment of Allergic Diseases

New research into allergic diseases is ongoing, especially the development and application of new biological agents. A researcher at the American College of Allergy, Asthma and Immunology (ACAAI), mentioned that traditional asthma treatments are ineffective for some people whose asthma cannot be controlled...

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What Factors Affect the Production and Secretion of IgE

Immunoglobulin E (IgE) antibodies are synthesized and secreted into the blood and tissues by B cells, and the regulation of their production and secretion is mediated by T cells. When specific allergens, such as pollen, mold, and dust mites, enter the body, the body's immune system stimulates T cells to produce and secrete the cytokines IL-4 and IL-13...

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B-1 Cells that Produce IgM Antibodies

B cells that produce IgM antibodies play a significant role in immune responses. These cells include B-1 cells and B-2 cells, which produce different types of IgM antibodies and function in different mechanisms with target organs...

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B-2 Cells that Produce IgM Antibodies

Cells are important immune cells that produce antibodies. Based on their different origins and functions, B cells can be divided into two types: B-1 cells and B-2 cells. B-2 cells are classical B lymphocytes that mainly exist in peripheral blood and lymphoid organs...

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Clinical Implications of Non-IgG Antibodies in Transplant Rejection

Organ transplantation provides an avenue for patients with end-stage organ failure to regain health and improve their quality of life. However, transplant rejection, characterized by the recipient's immune system attack on the donor organ remains a constant threat. Antibodies produced by the recipient's immune system are key players in this process...

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Non-IgG in Autoimmune Diseases: Pathogenic Contributors or Protective Allies?

Autoimmune diseases are conditions in which the body's immune system mistakenly attacks its own cells and organs. To understand autoimmunity, it is vital to understand the role of antibodies. Usually, antibodies are proteins produced by the body to combat invaders such as viruses and bacteria. But, in autoimmunity...

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The Role of IgM Antibodies in Pathology

Antibodies, also known as immunoglobulins, are crucial proteins produced by the immune system. They play a vital role in combating pathogens. When it comes to pathology, IgM antibodies are significant in disease conditions like infections, autoimmunity, and tumors...

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IgA Nephropathy - An Underestimated Kidney Disease

IgA Nephropathy, also known as Berger's Disease, is perhaps one of the most underestimated chronic kidney diseases. Characterized by the buildup of a specific antibody – Immunoglobulin A (IgA) – within the kidneys, this condition often goes unnoticed until it has advanced significantly...

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IgM Antibodies for Breast Cancer Diagnosis

Breast cancer is a prevalent malignant tumor among women, and early detection plays a pivotal role in treatment and outlook. Presently, mammography serves as the primary screening technique...

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T Cell Dependent IgA Class Switching

Immunoglobulin A (IgA) is a class of antibodies that play a major role in the immune function of mucous membranes. This class of antibodies is primarily produced in the gut, the largest immune organ in the body...

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T Cell Independent IgA Class Switching

Immunoglobulin A (IgA) is a type of antibody that plays an essential role in the immune function of mucous membranes. The production of IgA involves a process known as class-switch recombination (CSR)...

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The Crucial Role of IgA in Gut Health

The human body and the gut microbiota share a symbiotic relationship, together creating a complete ecosystem within our intestines...

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