Immunoglobulin M (IgM) is a central player in the immune system’s early response to infection. Its pentameric structure provides a high-avidity defense mechanism, allowing it to rapidly neutralize pathogens. Yet, despite itsRead More…
Unlocking the Power of IgE: A Novel Strategy Against Melanoma
Cancer immunotherapy continues to revolutionize treatment paradigms, yet advanced melanoma remains a challenging battlefield. Despite notable progress with immune checkpoint inhibitors like anti-PD-1 and CTLA-4 antibodies, long-term survival is still elusive forRead More…
Therapeutic IgY Antibody Discovery: A New Frontier in Biologics Development
Introduction: The Rise of IgY Antibodies in Therapeutic Research In recent years, the biopharmaceutical industry has witnessed a paradigm shift toward exploring alternative antibody formats beyond conventional IgG molecules. Among these, immunoglobulinRead More…
Unveiling the Metabolic-Epigenetic Axis in IgA Production and Gut Immunity
HIF-1α: Orchestrating Metabolic Rewiring for IgA Synthesis The hypoxic microenvironment of germinal centers (GCs) is a critical niche where B cells undergo clonal expansion and antibody diversification. Central to this process isRead More…
FcεRIβ – A Master Regulator of IgE Signaling and Its Therapeutic Implications in Allergic Inflammation
Allergic diseases, affecting over 300 million people globally, are characterized by dysregulated immune responses to harmless antigens. Central to this pathology is the high-affinity IgE receptor (FcεRI), a multimeric complex that orchestratesRead More…
New Advances in the Application of IgA Antibodies in Biosensor Development
Immunosensors are rapidly gaining traction in various diagnostic fields due to their high sensitivity and specificity. Among these, IgA antibodies have emerged as critical components in the development of advanced biosensors, particularlyRead More…
From Sensitization to Tolerance – How IgE, IgG, and IgA Shape the Future of Allergy Management
The complex interplay of immunoglobulins—IgE, IgG, and IgA—underpins the mechanisms of allergic diseases. These antibodies not only directly regulate allergic reactions but also play a crucial role in inducing immune tolerance throughRead More…
The Role of IgM N-Glycosylation in COVID-19 Severity and Complement Deposition: Insights from Recent Research
Introduction COVID-19, caused by the SARS-CoV-2 virus, has become a global health crisis since its emergence in late 2019. The severity of COVID-19 can vary widely among patients, ranging from asymptomatic orRead More…
Understanding Childhood IgA Vasculitis: Causes, Symptoms, and Management
Introduction Childhood IgA vasculitis, previously known as Henoch-Schönlein purpura, is a prevalent autoimmune disorder affecting small blood vessels, predominantly in children. This condition manifests through distinctive symptoms such as skin purpura, jointRead More…
New Insights into IgE Receptor Assembly: A Breakthrough in Allergy Research The Burden of Allergic Diseases
Allergic diseases, including asthma, allergic rhinitis, atopic dermatitis, and chronic urticaria, now affect more than 25-30% of the global population, with incidence rates continuing to rise. This growing prevalence places a significantRead More…