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As an unparalleled antibody development and manufacturer, Creative Biolabs is proud to offer high-quality non-IgG antibodies for both academic and industrial purposes. We offer the most diverse portfolio of customized non-IgG therapeutic antibody services based on the values of quality, timing, and price.

The understanding, function, production, development, and application of antibodies have undergone revolutionary changes since the advent of hybridoma technology in 1975 by Kohler and Milstein. Their high-affinities, specificities, diversities, immunoreactivities as well as other properties are fully exploited for antibodies as tools for disease detection or diagnosis, diseases prevention and treatment, vaccine development, proteins or pathogens characterization, laboratory assays and so forth. In recent years, with the progress of technologies and existing antibody development experience, scientific research focus has gradually turned to non-IgG antibodies to seek effectively therapeutic molecules. In recent years, non-IgG antibodies as bioactive molecules present promising potential in applications for disease therapy, clinical diagnosis, and vaccine development.

Non-IgG Antibody Application for Disease Therapy

As a class of bioactive molecules, antibody has always been one of the hotspots of concern due to its high affinity, targeting, and specificity. With the development of monoclonal antibody (mAb) and various engineering techniques, therapeutic IgG mAbs have been extensively applied for and made great achievements in the disease therapies. In recent years, more and more scientists and reports discover that non-IgG antibodies (mainly IgA, IgM, and IgE isotypes) may be the next generation of therapeutic antibodies for many indications, especially for the therapies of tumors, inflammation, and infections.

Mechanisms of action of therapeutic antibodies.Fig.1 Mechanisms of action of therapeutic antibodies. (Suzuki, 2015)

Non-IgG Antibody Application for Clinical Diagnosis

Non-IgG antibody diagnostic application mainly embodied in two aspects, —medical diagnosis and laboratory diagnosis. Specific antibodies detection is a common method of medical diagnosis, and serological examination is the best example. Microbes, proteins, self-antigens, tumor cells, and many other substances have their characteristic antigens. The presence and levels of specific antibody isotypes in samples taken from patients can provide assistance to human disorders diagnosis, not only for infections and inflammatory diseases but also for cancers and metabolic disorders. For example, increased IgA may indicate alcoholic cirrhosis and elevated IgM is a sign of viral hepatitis. On the other hand, non-IgG monoclonal antibodies can be employed as diagnostic reagents applied for a series of immunoassays, such as immunoprecipitation, radioimmunoassay, ELISA, etc.

Examples of the use of monoclonal antibodies to identify particular molecules and cell types in tissues. Fig.2 Examples of the use of monoclonal antibodies to identify particular molecules and cell types in tissues. (Heddy, 2001)

Non-IgG Antibody Application for Vaccine Development

One of the mechanisms of vaccine or vaccination is using attenuated or inactivated microorganisms or antigen substances to stimulate antibody production or active immune response in hosts to prevent microbial infection. Non-IgG antibodies, together with IgG antibody, play an important role in disease resistance as immunoactive molecules in the human body. Mucosal immunity of IgA and the first defense of IgM show great potential in vaccine development.

In Creative Biolabs, development of antibody products and services is our focus, as well as our flourishing section. We have won good reputations in terms of monoclonal antibody production and service. During the past few years, attributed the success to well-established platforms, abundant experience, and professional staff, we have creatively researched and developed a set of non-IgG therapeutic antibody service system to provide fast and high-quality non-IgG antibody products and related services to our universal customers.

For more detailed information, just feel free to contact us or send us an inquiry. Our professional scientists are always dedicated to assisting our clients with the most satisfactory solutions.

References

  1. Suzuki, M.; et al. Therapeutic antibodies: their mechanisms of action and the pathological findings they induce in toxicity studies. Journal of Toxicologic Pathology. 2015, 28(3): 133-139.
  2. Heddy, Z.; Peter, R. Z. Monoclonal Antibodies: Diagnostic Uses. Encyclopedia of Life Sciences (book). John Wiley & Sons, Ltd: Chichester. DOI: 10.1002/9780470015902.a0001205.pub3.

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!! For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.

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For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.

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