Antibodies, also named as immunoglobulins (Ig), are glycoproteins produced by the immune system that are mainly responsible for the response to pathogenic antigens (bacteria, viruses, toxins, tumor antigens, etc.) to protect the host against infections and some disorders. These antibodies are generally classified into five isotypes in humans: IgG, IgA, IgM, IgE, and IgD, each of which has different structure, properties, and special functions. The emergence and evolution of hybridoma technology and other innovative biotechnologies have pushed the development of IgG monoclonal antibodies to an unprecedented new height due to the advantages of easy production, diversity, high affinity, and specificity, etc. Whereas, the development of non-IgG antibodies has not been on track until recent years.
| Parameter | IgA | IgM | IgE |
| Structure | Dimeric or monomeric | Pentameric | Monomeric |
| Molecular Weight | ~385 kDa (dimeric form) | ~970 kDa | ~190 kDa |
| Presence in Body Fluids | Found in mucosal areas (saliva, tears, respiratory and intestinal secretions), breast milk | Present in blood and lymphatic fluid | Found in very low concentrations in serum |
| Primary Function | Mucosal immunity; prevents colonization by pathogens | Primary antibody in early immune response | Triggers allergic reactions and responses to parasitic infections |
| Production Sites | Secreted by plasma cells in mucosal membranes | Produced by plasma cells, primarily in the spleen and lymph nodes | Synthesized by plasma cells in response to allergens |
| Half-Life in Serum | ~5-6 days | ~5 days | ~2 days |
| Receptors | Binds to the polymeric immunoglobulin receptor (pIgR) for transport across epithelial cells | Activates the complement system by binding to complement protein C1 | Binds with high affinity to FcεRI on mast cells and basophils |
| Role in Complement Activation | Minimal involvement | Strong activator of the classical pathway | Does not activate the complement |
| Response to Antigen | Provides passive immunity to newborns through breastfeeding | First antibody produced in response to infection | Involved in hypersensitivity (allergic) responses |
| Distribution | Found in mucosal secretions and blood | Predominantly in blood | Predominantly bound to mast cells and basophils in tissues |
Product Portfolio
Based on existing research, scientists in Creative Biolabs found these non-IgG antibodies exhibit great potential and distinct preponderances in certain disease diagnoses and treatments. Therefore, we have invested generous talent and energy, and successfully constructed comprehensive technology platforms, aiming to offer the most diverse non-IgG antibody products as well as convenient and extensive services to customers all over the world. Here, we provide a broad spectrum of high-quality off-the-shelf non-IgG antibody products (mainly IgA, IgM, and IgE monoclonal/polyclonal antibodies and various assay kits) and various customized antibodies for both academic and commercial usage.
Antibodies, also named as immunoglobulins (Ig), are glycoproteins produced by the immune system that mainly responsible for the response to pathogenic antigens (bacteria, virus, toxins, tumor antigen, etc.) to protect the host against infections and some disorders. These antibodies are generally classified into five isotypes in humans: IgG, IgA, IgM, IgE, and IgD, each of which has different structure(s), properties and special functions. The emergence and evolution of hybridoma technology and other innovative biotechnologies have pushed the development of IgG monoclonal antibodies to an unprecedented new height due to advantages of easy production, diversity, high affinity, and specificity, etc. Whereas, the development of non-IgG antibodies has not been on track until recent years.
IgA antibodies, specialized for mucosal immunity, are valuable tools in both diagnostic and therapeutic applications. Creative Biolabs offers a high-quality range of IgA monoclonal and polyclonal antibodies, distinguished by their exceptional purity, specificity, and stability. Designed to meet the rigorous demands of clinical research, these IgA antibodies provide targeted neutralization of pathogens and are highly effective in modulating immune responses, making them ideal for advancing immunotherapy and vaccine development. With extensive expertise in non-IgG antibody development, we ensure each product meets stringent quality standards and performs optimally in various research and clinical settings.
IgM antibodies, or immunoglobulin M, are the largest and among the most versatile antibodies produced by the vertebrate immune system, playing a pivotal role in both primary and adaptive immune responses. Known for their high avidity and efficient antigen binding, IgM antibodies excel in activating the complement system, a process critical to cytotoxic reactions against pathogens and damaged cells. Notably, IgM antibodies have shown promising applications in cancer immunotherapy, with therapeutic potential demonstrated across various carcinoma models. Creative Biolabs provides a comprehensive selection of recombinant IgM antibodies, designed to meet diverse research and diagnostic needs. Our IgM antibodies, produced with exceptional purity and specificity, support reliable performance in immunoassays and therapeutic exploration.
IgE antibodies, or immunoglobulin E, are a specialized antibody class integral to immune responses against allergens and parasitic infections. Known for their unique role in allergic reactions, IgE antibodies bind to mast cells and basophils, triggering the release of histamines and other mediators essential for immune defense. Beyond allergic responses, recent research has shown that IgE antibodies may hold promise in cancer immunotherapy, as they exhibit high affinity for target cells and have demonstrated potential in targeting specific tumor antigens effectively. Creative Biolabs offers high-quality recombinant IgE antibodies, designed for research applications in allergy, immunology, and oncology. Leveraging advanced antibody engineering and rigorous quality control, our IgE antibodies support accurate, reliable results in complex immunological research, providing scientists with powerful tools to explore and expand the therapeutic possibilities of IgE.
Antibody ELISA kits are essential tools for the accurate quantification and detection of specific antibodies in various sample types, including serum, plasma, and cell culture supernatants. These kits provide high sensitivity and specificity, allowing researchers to detect even low concentrations of target antibodies. Designed for ease of use and reproducibility, they include pre-coated plates, standards, and all necessary reagents to streamline the assay process. Creative Biolabs offers a comprehensive selection of antibody ELISA kits tailored for diverse research needs, ensuring reliable results for applications in immunology, diagnostics, and biomarker discovery, especially for the detection of non-IgG antibodies.
Product Advantages
- Extensive Non-IgG Portfolio - Broad selection of high-quality non-IgG antibodies, including IgA, IgM, and IgE, for diverse research applications.
- High Purity and Specificity - Exceptional purity and specificity in antibody production, ensuring accurate results in diagnostics and immunoassays.
- Reliable Assay Kits: Comprehensive assay kits for reliable and sensitive quantification of non-IgG antibodies, supporting precise antibody detection.
- Customized Antibody Solutions: Custom antibody design options are available for targeted research needs, enabling tailored solutions for unique project requirements.
- Innovative IgE Antibodies: Unique IgE antibodies designed for allergy, immunology, and oncology research, aiding in the exploration of allergic reactions and tumor targeting.
- Advanced Engineering Platforms: Advanced technology platforms for antibody engineering, guaranteeing consistency, high performance, and reproducibility.
- Global Support and Assistance - Global customer support and custom project assistance, providing solutions that meet both academic and commercial research demands.
- Industry Expertise - Decades of expertise in non-IgG antibody development, ensuring quality products that meet stringent research and clinical standards.
If you need a non-IgG antibody product or are interested in non-IgG antibody development, just feel free to contact us or send an e-mail to us about your demands. We are looking forward to being a reliable supporter of your non-IgG antibody projects!
FAQs
Q1: What distinguishes non-IgG antibodies from IgG antibodies in research applications?
A: Non-IgG antibodies, such as IgA, IgM, and IgE, serve unique roles in immune responses and are valuable for studying functions beyond those associated with IgG, such as mucosal immunity, early immune response, and allergic reactions.
Q2: How does IgM antibody complement activation benefit research and therapeutic applications?
A: IgM antibodies effectively activate the complement system, which enhances immune responses by promoting cytotoxic and cytolytic reactions, making them beneficial for research in cancer and infectious disease immunotherapy.
Q3: Can non-IgG antibodies be used for therapeutic applications?
A: Yes, recent advancements indicate non-IgG antibodies like IgM and IgE may be used therapeutically, especially in immunotherapy, due to their unique properties in immune modulation.
Q4: What types of assay kits are available for non-IgG antibody detection?
A: Creative Biolabs offers high-sensitivity ELISA kits tailored for non-IgG antibodies, enabling accurate detection of antibodies like IgA, IgM, and IgE across various sample types.
Q5: Are Creative Biolabs' antibody products compatible with immunoassays?
A: Yes, our high-purity non-IgG antibodies are specifically designed for reliable performance in various immunoassays, supporting diagnostics and research studies.
Q6: How are non-IgG antibodies stored to ensure stability?
A: Non-IgG antibody products from Creative Biolabs are stored at 4°C or -20°C to maintain their stability and functionality.
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!! For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.
