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IgA Antibody Application for Diagnosis

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Creative Biolabs is a professional CRO company that has developed a comprehensive service chain in developing non-IgG therapeutic antibody-based immunotherapies. With in-depth expertise in molecular modeling, structural analysis, as well as in-vivo and in-vitro studies, we have successfully completed a number of projects on non-IgG antibodies development and applications. Armed with successful experience and specialized knowledge, we provide customized diagnosis services using recombinant IgA antibodies.

IgA Application for Diagnosis

As a member of the first defense, immunoglobulin A (IgA) exerts a significant role in protecting from exogenous invasion and endogenous anomalies of the body. Beyond its essential role in mucosal immunity, abnormal IgA antibodies recently have been demonstrated to be associated with a variety of disorders, including autoimmune diseases, IgA nephropathy, celiac disease and Henoch-Schönlein purpura (HSP). All these critical roles and functions lay the foundation for the application of antibodies in diseases diagnosis.

More and more studies have confirmed the potential diagnostic manner in several diseases, among which acute congenital, acquired toxoplasmosis, mumps, and tumors are typical examples. Take tuberculosis as an example, the data have shown that toxoplasma-specific IgA antibodies are positive in most patients with toxoplasmosis, and relatively higher titers of IgA antibodies can be determined at the early stages and progression of diseases. Consequently, specific IgA antibodies can be useful and complementary indicators for tuberculosis diagnosis as well as progression and treatment monitoring.

The Assays for IgA Diagnosis

Creative Biolabs can provide a full range of IgA antibodies of different species, including human, rat, mouse, rabbit as well as monkey. Moreover, we have established a panel of detection assays for specific IgA. Our IgA assays include, but are not limited to:

Enzyme-linked immunosorbent assay (ELISA)

ELISA is a common tool for detecting and quantifying of IgA antibodies. We have generated a number of ready-to-use ELISA kits to meet any requirement of our worldwide customers. This ELISA assay is a reliable, rapid and accurate system and has been widely used for a wide variety of disease diagnosis. All the assays for IgA ELISA tests are highly specific and sensitive.

IgA immunosorbent agglutination assay

IgA immunosorbent agglutination assay (ISAGA A) is a useful agglutination detection system for diagnosing congenital toxoplasmosis (CT), which is considered to be more sensitive than ELISA in IgA determination. In this assay, a serial dilution of monoclonal anti-human IgA is coated with 96-well microtitration plates, and the plate has been washed for at least three times and then is used for further identifying agglutination. Then the negative or positive result of samples is collected and analyzed.

Schematic workflow depicting sequential molecular binding events of the sandwich ELISA.Fig.1 Schematic workflow depicting sequential molecular binding events of the sandwich ELISA. (Thaitrong, 2013)

With over years of experience in services of non-IgG antibody discovery, Creative Biolabs offers a large collection of IgA based diagnostic assays for different diseases and targets. Our client-focused, integrated team will anticipate challenges and overcome difficulties to convert these potential targets and diagnostic assays into preclinical trials.

For more information, please feel free to contact us or send us an inquiry.

Reference

  1. Thaitrong, N., et al. Implementation of microfluidic sandwich ELISA for superior detection of plant pathogens. PLoS One. 2013, 8(12): e83231.

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