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Rat Anti-Mouse FASLG IgM Monoclonal Antibody (A11) [Alexa Fluor® 488] (CAT#: NGM-060)

This product is a conjugated anti-Mouse FASLG Monoclonal antibody (A11) generated from the Rat. This antibody can be used for FC, IHC.

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Antibody Isotype IgM
Clone A11
Applications FC; IHC
Target FASLG
Host Rat
Clonality Monoclonal
Antibody Type Primary antibody
Species Reactivity Mouse
Immunogen Recombinant mouse tumor necrosis factor ligand superfamily member 6, aa., 196-220, RGQSCNNQPLNHKVY MRNSKYPEDL
Format Liquid
Buffer 50mM Sodium Borate
Storage Store at 4° C in dark. Do not freeze.

Target Information

Target Name FASLG
Alternative Names Fas Ligand; Tumor Necrosis Factor Ligand Superfamily Member 6; Apoptosis Antigen Ligand; Fas Antigen Ligand; CD95 Ligand; TNFSF6; CD178; CD95L; FasL; Mutant Tumor Necrosis Factor Family Member 6; Apoptosis (APO-1) Antigen Ligand 1; Tumor Necrosis Factor Ligand 1A; CD178 Antigen; ALPS1B; TNLG1A
Related Disease Autoimmune Lymphoproliferative Syndrome; Lung Cancer
Gene ID 356
UniProt ID P48023
Target Overview Tumor necrosis factor ligand superfamily member 6 is a cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. The soluble form of Tumor necrosis factor ligand superfamily member 6 induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways. Can induce apoptosis but does not appear to be essential for this process.
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For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.






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