Click the button below to contact us or submit your feedback about this product.
This product is an unconjugated anti-Mouse FASLG Monoclonal antibody (A11) generated from the Rat. This antibody can be used for FC, IHC.
Please feel free to contact us for a quote and further discussion with our scientists. Datasheets
specifications |
|
|---|---|
| Antibody Isotype | IgM |
| Clone | A11 |
| Applications | FC; IHC |
| Target | FASLG |
| Host | Rat |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| Species Reactivity | Mouse |
| Immunogen | Recombinant mouse tumor necrosis factor ligand superfamily member 6, aa., 196-220, RGQSCNNQPLNHKVY MRNSKYPEDL |
| Format | Liquid |
| Buffer | PBS |
| Storage | Store at 4° C. |
Target Information |
|
|---|---|
| Target Name | FASLG |
| Alternative Names | Fas Ligand; Tumor Necrosis Factor Ligand Superfamily Member 6; Apoptosis Antigen Ligand; Fas Antigen Ligand; CD95 Ligand; TNFSF6; CD178; CD95L; FasL; Mutant Tumor Necrosis Factor Family Member 6; Apoptosis (APO-1) Antigen Ligand 1; Tumor Necrosis Factor Ligand 1A; CD178 Antigen; ALPS1B; TNLG1A |
| Related Disease | Autoimmune Lymphoproliferative Syndrome; Lung Cancer |
| Gene ID | 356 |
| UniProt ID | P48023 |
| Target Overview | Tumor necrosis factor ligand superfamily member 6 is a cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. The soluble form of Tumor necrosis factor ligand superfamily member 6 induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways. Can induce apoptosis but does not appear to be essential for this process. |
Click the button below to contact us or submit your feedback about this product.
KINDLY NOTE
!! For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.
!! Custom antibodies beyond the list can be tailored flexibly. Please directly Email us your specific demands.
CONTACT US
© 2024 Creative Biolabs All Rights Reserved
Datasheet
