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This product is an unconjugated anti-TNF-α Monoclonal antibody (TNF706 + P/T2) generated from the Mouse. This antibody can be used for IHC.
Please feel free to contact us for a quote and further discussion with our scientists. Datasheets
specifications |
|
|---|---|
| Antibody Isotype | IgM |
| Clone | TNF706 + P/T2 |
| Applications | IHC |
| Target | TNF-α |
| Host | Mouse |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| Species Reactivity | Human, Mouse, Rat, Rabbit, Canine, Feline, Zebrafish |
| Immunogen | A hexadecapeptide corresponding to aa115-130 of Human TNF-alpha, conjugated to Thyroglobulin (P/T2) |
| Format | Liquid |
| Buffer | 10 mM PBS with 0.05% BSA |
| Storage | Store at 4C. |
Target Information |
|
|---|---|
| Target Name | TNF-α |
| Alternative Names | Tumor Necrosis Factor; TNF-Alpha; TNFSF2; Tumor Necrosis Factor Ligand Superfamily Member 2; TNFA; DIF; Tumor Necrosis Factor Ligand 1F; Tumor Necrosis Factor-Alpha; TNF Superfamily Member 2; APC1 Protein; Cachectin; TNLG1F; TNF |
| Related Disease | Asthma; Malaria |
| Gene ID | 7124 |
| UniProt ID | P01375 |
| Target Overview | Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective. Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6. The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells. |
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Datasheet
