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Mouse Anti-TNF-α IgM Monoclonal Antibody (TNF706 + P/T2) [FITC] (CAT#: NGM-254)

This product is a conjugated anti-TNF-α Monoclonal antibody (TNF706 + P/T2) generated from the Mouse. This antibody can be used for IHC.

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Antibody Isotype IgM
Clone TNF706 + P/T2
Applications IHC
Target TNF-α
Host Mouse
Clonality Monoclonal
Antibody Type Primary antibody
Species Reactivity Human, Mouse, Rat, Rabbit, Canine, Feline, Zebrafish
Immunogen A hexadecapeptide corresponding to aa115-130 of Human TNF-alpha, conjugated to Thyroglobulin (P/T2).
Format Liquid
Buffer PBS
Storage Store at 4° C in dark. Do not freeze.

Target Information

Target Name TNF-α
Alternative Names Tumor Necrosis Factor; TNF-Alpha; TNFSF2; Tumor Necrosis Factor Ligand Superfamily Member 2; TNFA; DIF; Tumor Necrosis Factor Ligand 1F; Tumor Necrosis Factor-Alpha; TNF Superfamily Member 2; APC1 Protein; Cachectin; TNLG1F; TNF
Related Disease Asthma; Malaria
Gene ID 7124
UniProt ID P01375
Target Overview Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective. Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6. The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
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For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.






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