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Mouse anti-erbB-2 (Her-2/neu) IgE Monoclonal Antibody (NGE14-TT) (CAT#: NGE-041)

This product is an unconjugated anti-erbB-2 (Her-2/neu) Monoclonal Antibody (NGE14-TT) gernerated from the mouse. This antibody can be used for applications: ELISA; FC; IHC.

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Antibody Isotype IgE
Clone NGE14-TT
Applications ELISA; FC; IHC
Target ERBB2
Host Mouse
Clonality Monoclonal
Antibody Type Primary antibody
Species Reactivity Human
Immunogen Human epidermoid carcinoma A431 cells expressing EGFR.
Format Liquid
Buffer PBS
Storage Store at 4°C for short-term and -20°C for long-term. Avoid repeated freeze-thaw cycles.

Target Information

Target Name ERBB2
Alternative Names Erb-B2 Receptor Tyrosine Kinase 2; HER2; NEU; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2; Tyrosine Kinase-Type Cell Surface Receptor HER2; Neuro/Glioblastoma Derived Oncogene Homolog 2; Human Epidermal Growth Factor Receptor 2; Receptor Tyrosine-Protein Kinase ErbB-2; Metastatic Lymph Node Gene 19 Protein; Proto-Oncogene C-ErbB-2; Proto-Oncogene Neu; MLN 19; CD340; HER-2; NGL; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncoprotein 2; Neuroblastoma/Glioblastoma Derived Oncogene Homolog; C-Erb B2/Neu Protein; CD340 Antigen; HER-2/Neu; Herstatin; P185erbB2; MLN19; TKR1
Related Disease Glioma Susceptibility 1; Gastric Cancer
Gene ID 2064
UniProt ID P04626
Target Overview Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
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