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This product is an unconjugated anti-erbB-2 (Her-2/neu) Monoclonal Antibody (NGE15-TT) gernerated from the human. This antibody can be used for applications: ELISA; FC; IHC.
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specifications |
|
|---|---|
| Antibody Isotype | IgE |
| Clone | NGE15-TT |
| Applications | ELISA; FC; IHC |
| Target | ERBB2 |
| Host | Human |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| Species Reactivity | Human |
| Immunogen | Human epidermoid carcinoma A431 cells expressing EGFR. |
| Format | Liquid |
| Buffer | PBS |
| Storage | Store at 4°C for short-term and -20°C for long-term. Avoid repeated freeze-thaw cycles. |
Target Information |
|
|---|---|
| Target Name | ERBB2 |
| Alternative Names | Erb-B2 Receptor Tyrosine Kinase 2; HER2; NEU; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2; Tyrosine Kinase-Type Cell Surface Receptor HER2; Neuro/Glioblastoma Derived Oncogene Homolog 2; Human Epidermal Growth Factor Receptor 2; Receptor Tyrosine-Protein Kinase ErbB-2; Metastatic Lymph Node Gene 19 Protein; Proto-Oncogene C-ErbB-2; Proto-Oncogene Neu; MLN 19; CD340; HER-2; NGL; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncoprotein 2; Neuroblastoma/Glioblastoma Derived Oncogene Homolog; C-Erb B2/Neu Protein; CD340 Antigen; HER-2/Neu; Herstatin; P185erbB2; MLN19; TKR1 |
| Related Disease | Glioma Susceptibility 1; Gastric Cancer |
| Gene ID | 2064 |
| UniProt ID | P04626 |
| Target Overview | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. |
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Datasheet
