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Rat Anti-Mouse CD43 IgM Monoclonal Antibody (R2/60) [Alexa Fluor® 532] (CAT#: NGM-263)

This product is a conjugated anti-Mouse CD43 Monoclonal antibody (R2/60) generated from the Rat. This antibody can be used for WB, FC.

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Antibody Isotype IgM
Clone R2/60
Applications WB; FC
Target CD43
Host Rat
Clonality Monoclonal
Antibody Type Primary antibody
Species Reactivity Mouse
Immunogen CD43
Format Liquid
Buffer 50mM Sodium Borate
Storage Store at 4° C in dark. Do not freeze.

Target Information

Target Name CD43
Alternative Names Sialophorin; Leukosialin; GPL115 ; Sialophorin (GpL115, Leukosialin, CD43); Leukocyte Sialoglycoprotein; Galactoglycoprotein; GALGP; LSN; CD43 Antigen; SPN
Related Disease Adenoid Basal Cell Carcinoma; Wiskott-Aldrich Syndrome
Gene ID 20737
UniProt ID P15702
Target Overview Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells. Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR. Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1. The cytoplasmic tail of CD43: Protects cells from apoptotic signals, promoting cell survival.
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