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Rat Anti-HSP90 IgM Monoclonal Antibody (2D12) (CAT#: NGM-146)

This product is an unconjugated anti-HSP90 Monoclonal antibody (2D12) generated from the Rat. This antibody can be used for WB, IP.

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specifications

Antibody Isotype IgM
Clone 2D12
Applications WB; IP
Target HSP90
Host Rat
Clonality Monoclonal
Antibody Type Primary antibody
Species Reactivity Mouse, Human, Rat, Bovine, Chicken, Rabbit, Primate, Caine, Sheep
Immunogen Native mouse Hsp90
Format Liquid
Buffer PBS with 50% Glycerol, pH 7.2
Storage Store at -20° C to -80° C. Avoid freeze-thaw cycles.

Target Information

Target Name HSP90
Alternative Names Heat shock protein HSP 90-alpha; Heat Shock Protein 90 Alpha Family Class A Member 1; LPS-Associated Protein 2; Heat Shock 86 Kda; HSP90A; HSP90N; HSP 86; HSPC1; Hsp89
Related Disease Candidiasis; Epidermolysis Bullosa Acquisita
Gene ID 15519
UniProt ID P07901
Target Overview Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation. Mediates the association of TOMM70 with IRF3 or TBK1 in mitochodria outer membrane which promotes host antiviral response.
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!! For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.

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For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.

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