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Rabbit anti-Human IgM Polyclonal Antibody (CAT#: NITT-1224-TT11)
This product is an unconjugated Human IgM Polyclonal Antibody gernerated from the Rabbit. It is usually applied for WB, IHC, ICC, IP.
Please feel free to contact us for a quote and further discussion with our scientists. Datasheets
specifications |
|
|---|---|
| Antibody Isotype | IgG |
| Clone | Polyclonal |
| Applications | WB; IHC; ICC; IP |
| Target | IgM |
| Host | Rabbit |
| Species Reactivity | Human |
| Immunogen | Recombinant Human IgM, NITT-1024-TT12 |
| Format | Liquid |
| Buffer | 0.01M PBS with 50% glycerol, pH7.4 |
| Storage | Store at 4°C for short-term and -20°C for long-term. Avoid repeated freeze-thaw cycles. |
Target Information |
|
|---|---|
| Target Name | IgM |
| Alternative Names | MU; VH; AGM1; Igm; muH; Igh6; Igh-6; Igh-M |
| Gene ID | 3507 |
| UniProt ID | P01871 |
| Target Overview | Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes, joining (J) genes, and diversity (D) genes. The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma. |
Datasheet
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For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.
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For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.