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This product is an unconjugated anti-Thyroglobulin Monoclonal antibody (12G9) generated from the Mouse. This antibody can be used for ELISA.
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specifications |
|
|---|---|
| Antibody Isotype | IgM |
| Clone | 12G9 |
| Applications | ELISA |
| Target | Thyroglobulin |
| Host | Mouse |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| Species Reactivity | Human, Mouse, Rat, Porcine, Bovine, Canine, Feline |
| Immunogen | Thyroglobulin from human thyroid gland |
| Format | Liquid |
| Buffer | PBS, pH 7.4 |
| Storage | Store at 4° C. |
Target Information |
|
|---|---|
| Target Name | Thyroglobulin |
| Alternative Names | AITD3; TGN; TG; Tg |
| Related Disease | Thyroid Dyshormonogenesis 3; Autoimmune Thyroid Disease 3 |
| Gene ID | 7038 |
| UniProt ID | P01266 |
| Target Overview | Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen. Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream. One dimer produces 7 thyroid hormone molecules. |
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Datasheet
