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This product is an unconjugated anti-SLC8A3 Monoclonal antibody (C2C12) generated from the Mouse. This antibody can be used for WB, FC, IF, IHC, IP.
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specifications |
|
|---|---|
| Antibody Isotype | IgM |
| Clone | C2C12 |
| Applications | WB; FC; IF; IHC; IP |
| Target | SLC8A3 |
| Epitope | This antibody recognizes an epitope between amino acids 371-525 on the intracellular side of the plasma membrane. |
| Host | Mouse |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| Species Reactivity | Human, Mouse, Rat, Rabbit, Porcine, Bovine, Canine, Guinea pig |
| Immunogen | Purified canine cardiac sodium/calcium exchanger |
| Format | Liquid |
| Buffer | PBS with BSA |
| Storage | Store at -20° C to -80° C. Avoid freeze-thaw cycles. |
Target Information |
|
|---|---|
| Target Name | SLC8A3 |
| Alternative Names | Solute Carrier Family 8 Member A3; NCX3; Solute Carrier Family 8 (Sodium/Calcium Exchanger) Member 3; Na(+)/Ca(2+)-Exchange Protein 3; Sodium/Calcium Exchanger 3; Solute Carrier Family 8 Member 3 |
| Related Disease | Spastic Paraplegia 24 Autosomal Recessive; Epilepsy With Generalized Tonic-Clonic Seizures |
| Gene ID | 6547 |
| UniProt ID | P57103 |
| Target Overview | Solute Carrier Family 8 Member A3 mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Required for normal oligodendrocyte differentiation and for normal myelination. Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis. |
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Datasheet
