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This product is an unconjugated anti-Rat CD3δ Monoclonal antibody (1F4) generated from the Mouse. This antibody can be used for FC, IHC, IP.
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specifications |
|
|---|---|
| Antibody Isotype | IgM |
| Clone | 1F4 |
| Applications | FC; IHC; IP |
| Target | CD3δ |
| Host | Mouse |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| Species Reactivity | Rat |
| Immunogen | F344 rat T cells stimulated with PMA (TPA) and calcium ionophore |
| Format | Liquid |
| Buffer | PBS |
| Storage | Store at 4° C for short term and at -20° C or lower for long term. Avoid freeze-thaw cycles. |
Target Information |
|
|---|---|
| Target Name | CD3δ |
| Alternative Names | CD3d Molecule; CD3d Antigen, Delta Polypeptide (TiT3 Complex); T-Cell Surface Glycoprotein CD3 Delta Chain; CD3d Molecule Delta (CD3-TCR Complex); T-Cell Receptor T3 Delta Chain; T3D; CD3 Delta Subunit; CD3d Antigen; CD3 Delta; IMD19; CD3D |
| Related Disease | Immunodeficiency 19; T-B+ Severe Combined Immunodeficiency Due To Cd3delta/Cd3epsilon/Cd3zeta |
| Gene ID | 915 |
| UniProt ID | P04234 |
| Target Overview | Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells. |
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Datasheet