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Mouse Anti-Podocalyxin IgM Monoclonal Antibody (2A4) (CAT#: NGM-145)

This product is an unconjugated anti-Podocalyxin Monoclonal antibody (2A4) generated from the Mouse. This antibody can be used for WB, FC, IF, IHC.

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Antibody Isotype IgM
Clone 2A4
Applications WB; FC; IF; IHC
Target Podocalyxin
Host Mouse
Clonality Monoclonal
Antibody Type Primary antibody
Species Reactivity Human, Rat, Rabbit
Immunogen Recombinant human Podocalyxin protein fragment containing the intracellular, transmembrane, and part of the extracellular domain
Format Liquid
Buffer 10 mM PBS with 0.05% BSA
Storage Store at 4° C.

Target Information

Target Name Podocalyxin
Alternative Names Podocalyxin Like; Gp200 ; PCLP; Podocalyxin-Like Protein 1; GCTM-2 Antigen; PCLP-1; PODXL1; Gp135; PDX; Podocalyxin-Like; PODXL; PCLP1
Related Disease Atypical Juvenile Parkinsonism; Parkinson Disease 2 Autosomal Recessive Juvenile
Gene ID 5420
UniProt ID O00592
Target Overview Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.
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For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.






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