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This product is an unconjugated anti-Podocalyxin Monoclonal antibody (2A4) generated from the Mouse. This antibody can be used for WB, FC, IF, IHC.
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specifications |
|
|---|---|
| Antibody Isotype | IgM |
| Clone | 2A4 |
| Applications | WB; FC; IF; IHC |
| Target | Podocalyxin |
| Host | Mouse |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| Species Reactivity | Human, Rat, Rabbit |
| Immunogen | Recombinant human Podocalyxin protein fragment containing the intracellular, transmembrane, and part of the extracellular domain |
| Format | Liquid |
| Buffer | 10 mM PBS with 0.05% BSA |
| Storage | Store at 4° C. |
Target Information |
|
|---|---|
| Target Name | Podocalyxin |
| Alternative Names | Podocalyxin Like; Gp200 ; PCLP; Podocalyxin-Like Protein 1; GCTM-2 Antigen; PCLP-1; PODXL1; Gp135; PDX; Podocalyxin-Like; PODXL; PCLP1 |
| Related Disease | Atypical Juvenile Parkinsonism; Parkinson Disease 2 Autosomal Recessive Juvenile |
| Gene ID | 5420 |
| UniProt ID | O00592 |
| Target Overview | Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. |
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Datasheet
