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This product is an unconjugated anti-Nitric Oxide Synthase 2 Monoclonal antibody (NOS-3F7-B11 B5) generated from the Mouse. This antibody can be used for WB, IF, IHC, IP.
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specifications |
|
|---|---|
| Antibody Isotype | IgM |
| Clone | NOS-3F7-B11 B5 |
| Applications | WB; IF; IHC; IP |
| Target | Nitric Oxide Synthase 2 |
| Host | Mouse |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| Species Reactivity | Human, Mouse, Rat, Bovine |
| Immunogen | Purified bovine bNOS |
| Format | Liquid |
| Buffer | Ascites |
| Storage | Store at -20° C to -80° C. Avoid freeze-thaw cycles. |
Target Information |
|
|---|---|
| Target Name | Nitric Oxide Synthase 2 |
| Alternative Names | HEP-NOS; INOS; Nitric Oxide Synthase 2A (Inducible, Hepatocytes); Peptidyl-Cysteine S-Nitrosylase NOS2; Nitric Oxide Synthase Inducible; Inducible NO Synthase; Hepatocyte NOS; Inducible NOS; NOS2A; NOS 2; Nitric Oxide Synthase Macrophage; NOS Type II; NOS2 |
| Related Disease | Malaria; Meningioma Familial |
| Gene ID | 4843 |
| UniProt ID | P35228 |
| Target Overview | Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8. |
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Datasheet
