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This product is an unconjugated anti-Mouse HLA-DRB1 Monoclonal antibody (25-9-3) generated from the Mouse. This antibody can be used for FC, IHC.
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specifications |
|
|---|---|
| Antibody Isotype | IgM, κ |
| Clone | 25-9-3 |
| Applications | FC; IHC |
| Target | HLA-DRB1 |
| Host | Mouse |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| Species Reactivity | Mouse |
| Immunogen | C3H.SW mouse splenocytes |
| Format | Liquid |
| Buffer | 0.1M BBS, pH 8.2 |
| Storage | Store at 4° C. |
Target Information |
|
|---|---|
| Target Name | HLA-DRB1 |
| Alternative Names | Major Histocompatibility Complex, Class II, DR Beta 1; Major Histocompatibility Complex, Class II, DR Beta 1 Precursor; HLA Class II Histocompatibility Antigen, DR-1 Beta Chain; HLA Class II Histocompatibility Antigen, DRB1 Beta Chain; MHC Class II HLA-DR Beta 1 Chain; Human Leucocyte Antigen DRB1; Human Leukocyte Antigen DRB1; Lymphocyte Antigen DRB1; HLA-DR1B; HLA-DRB; DRB1; SS1 |
| Related Disease | Sarcoidosis 1; Multiple Sclerosis |
| Gene ID | 3123 |
| UniProt ID | P01911 |
| Target Overview | A beta chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the alpha chain HLA-DRA, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DRB1-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells. Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes. In the tumor microenvironment, presents antigenic peptides that are primarily generated in tumor-resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins. Presents peptides derived from intracellular proteins that are trapped in autolysosomes after macroautophagy, a mechanism especially relevant for T cell selection in the thymus and central immune tolerance. The selection of the immunodominant epitopes follows two processing modes: 'bind first, cut/trim later' for pathogen-derived antigenic peptides and 'cut first, bind later' for autoantigens/self-peptides. The anchor residue at position 1 of the peptide N-terminus, usually a large hydrophobic residue, is essential for high affinity interaction with MHCII molecules. |
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Datasheet
