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Mouse Anti-Human TERT Monoclonal Antibody (2D8)

Mouse Anti-Human TERT Monoclonal Antibody (2D8) (CAT#: NGM-014)

This product is an unconjugated anti-Human TERT Monoclonal antibody (2D8) generated from the Mouse. This antibody can be used for WB, FC, IF, IHC.

Please feel free to contact us for a quote and further discussion with our scientists. Datasheets

specifications
Antibody Isotype IgM
Clone 2D8
Applications WB; FC; IF; IHC
Target TERT
Host Mouse
Clonality Monoclonal
Antibody Type Primary antibody
species Reactivity Human
Immunogen Recombinant human Telomerase reverse transcriptase from insect cells.
Format Liquid
Buffer Ascites
Storage Store at -20° C to -80° C. Avoid freeze-thaw cycles.
Target Information
Target Name TERT
Alternative Names Telomerase reverse transcriptase; HEST2; Telomerase catalytic subunit; Telomerase-associated protein 2; TP2; TRT; CMM9; EST2; TCS1; hTRT; DKCA2; DKCB4; hEST2; PFBMFT1
Related Disease Dyskeratosis Congenita Autosomal Dominant 2; Pulmonary Fibrosis And/Or Bone Marrow Failure Telomere-Related 1
Gene ID 7015
UniProt ID O14746
Target Overview Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.

KINDLY NOTE
!! For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.

!! Custom antibodies beyond the list can be tailored flexibly. Please directly Email us your specific demands.

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For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.

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