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This product is an unconjugated anti-Human TERT Monoclonal antibody (2D8) generated from the Mouse. This antibody can be used for WB, FC, IF, IHC.
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specifications |
|
|---|---|
| Antibody Isotype | IgM |
| Clone | 2D8 |
| Applications | WB; FC; IF; IHC |
| Target | TERT |
| Host | Mouse |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| Species Reactivity | Human |
| Immunogen | Recombinant human Telomerase reverse transcriptase from insect cells. |
| Format | Liquid |
| Buffer | Ascites |
| Storage | Store at -20° C to -80° C. Avoid freeze-thaw cycles. |
Target Information |
|
|---|---|
| Target Name | TERT |
| Alternative Names | Telomerase reverse transcriptase; HEST2; Telomerase catalytic subunit; Telomerase-associated protein 2; TP2; TRT; CMM9; EST2; TCS1; hTRT; DKCA2; DKCB4; hEST2; PFBMFT1 |
| Related Disease | Dyskeratosis Congenita Autosomal Dominant 2; Pulmonary Fibrosis And/Or Bone Marrow Failure Telomere-Related 1 |
| Gene ID | 7015 |
| UniProt ID | O14746 |
| Target Overview | Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis. |
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