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Mouse Anti-Human Presenilin-2 IgM Monoclonal Antibody (198C679.2.) (CAT#: NGM-200)

This product is an unconjugated anti-Human Presenilin-2 Monoclonal antibody (198C679.2.) generated from the Mouse. This antibody can be used for WB.

Please feel free to contact us for a quote and further discussion with our scientists. Datasheets


Antibody Isotype IgM
Clone 198C679.2.
Applications WB
Target Presenilin-2
Host Mouse
Clonality Monoclonal
Antibody Type Primary antibody
Species Reactivity Human
Immunogen Recombinant partial human Presenilin-2
Format Liquid
Buffer Tissue culture supernatant
Storage Store at 4° C for short term and at -20° C or lower for long term. Avoid freeze-thaw cycles.

Target Information

Target Name Presenilin-2
Alternative Names STM2; PS2; Presenilin-2; AD3LP; STM-2; AD3L; E5-1; PS-2; CMD1V; PSEN2; PSNL2
Related Disease Alzheimer Disease 4; Cardiomyopathy Dilated 1V
Gene ID 5664
UniProt ID P49810
Target Overview Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria.
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For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.






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