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This product is an unconjugated anti-Human Presenilin-2 Monoclonal antibody (198C679.2.) generated from the Mouse. This antibody can be used for WB.
Please feel free to contact us for a quote and further discussion with our scientists. Datasheets
specifications |
|
|---|---|
| Antibody Isotype | IgM |
| Clone | 198C679.2. |
| Applications | WB |
| Target | Presenilin-2 |
| Host | Mouse |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| Species Reactivity | Human |
| Immunogen | Recombinant partial human Presenilin-2 |
| Format | Liquid |
| Buffer | Tissue culture supernatant |
| Storage | Store at 4° C for short term and at -20° C or lower for long term. Avoid freeze-thaw cycles. |
Target Information |
|
|---|---|
| Target Name | Presenilin-2 |
| Alternative Names | STM2; PS2; Presenilin-2; AD3LP; STM-2; AD3L; E5-1; PS-2; CMD1V; PSEN2; PSNL2 |
| Related Disease | Alzheimer Disease 4; Cardiomyopathy Dilated 1V |
| Gene ID | 5664 |
| UniProt ID | P49810 |
| Target Overview | Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria. |
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Datasheet
