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This product is an unconjugated anti-Human Mucin-4 Monoclonal antibody (CBFYM-0252) generated from the Mouse. This antibody can be used for ELISA, FC, IHC, IP.
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specifications |
|
|---|---|
| Antibody Isotype | IgM |
| Clone | CBFYM-0252 |
| Applications | ELISA; FC; IHC; IP |
| Target | Mucin-4 |
| Host | Mouse |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| Species Reactivity | Human |
| Immunogen | Coll2-23 colorectal cancer cells and live PC/AA polyposis coli cells |
| Format | Liquid |
| Buffer | PBS |
| Storage | Store at 4° C for short term and at -20° C or lower for long term. Avoid freeze-thaw cycles. |
Target Information |
|
|---|---|
| Target Name | Mucin-4 |
| Alternative Names | Mucin 4 Cell Surface Associated; Pancreatic Adenocarcinoma Mucin; Mucin 4 Tracheobronchial; Ascites Sialoglycoprotein; Tracheobronchial Mucin; Testis Mucin; MUC-4; ASGP; HSA276359; MUC4 |
| Related Disease | Filamentary Keratitis; Biliary Tract Cancer |
| Gene ID | 4585 |
| UniProt ID | Q99102 |
| Target Overview | May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelial cells segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. |
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Datasheet
