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This product is an unconjugated anti-Human CD59 Monoclonal antibody (193-27) generated from the Mouse. This antibody can be used for IF, FC, Funcs.
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specifications |
|
|---|---|
| Antibody Isotype | IgM, κ |
| Clone | 193-27 |
| Applications | IF; FC; Funcs |
| Target | CD59 |
| Host | Mouse |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| Species Reactivity | Human |
| Immunogen | Stimulated human leukocytes |
| Format | Liquid |
| Buffer | 10 mM PBS with 0.05% BSA |
| Storage | Store at 4° C. |
Target Information |
|
|---|---|
| Target Name | CD59 |
| Alternative Names | CD59 glycoprotein; 1F5 antigen; 20 kDa homologous restriction factor; HRF-20; MAC-inhibitory protein; MAC-IP; MEM43 antigen; Membrane attack complex inhibition factor; MACIF; Membrane inhibitor of reactive lysis; MIRL; Protectin |
| Related Disease | Hemolytic Anemia Cd59-Mediated With Or Without Immune-Mediated Polyneuropathy; Hemoglobinuria |
| Gene ID | 966 |
| UniProt ID | P13987 |
| Target Overview | Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. |
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Datasheet
