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This product is a conjugated anti-Human CD41/CD61 Monoclonal antibody (PAC-1) generated from the Mouse. This antibody can be used for FC, IF.
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specifications |
|
|---|---|
| Antibody Isotype | IgM, κ |
| Clone | PAC-1 |
| Applications | FC; IF |
| Target | CD41/CD61 |
| Epitope | This antibody recognizes an activation-induced conformational epitope PAC-1. |
| Host | Mouse |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| Species Reactivity | Human |
| Immunogen | Human platelets |
| Format | Liquid |
| Buffer | PBS |
| Storage | Store at 4° C in dark. Do not freeze. |
Target Information |
|
|---|---|
| Target Name | CD41/CD61 |
| Alternative Names | Integrin Subunit Alpha 2b; Integrin, Alpha 2b (Platelet Glycoprotein IIb Of IIb/IIIa Complex, Antigen CD41); Platelet Glycoprotein IIb Of IIb/IIIa Complex; Protein Phosphatase 1, Regulatory Subunit 93; Platelet Membrane Glycoprotein IIb; Integrin Alpha-IIb; GPalpha IIb; PPP1R93; CD41B; GPIIb; CD41; GP2B; Integrin, Alpha 2b (Platelet Glycoprotein IIb Of IIb/IIIa Complex, Antigen CD41B); Platelet Fibrinogen Receptor Alpha Subunit; Platelet-Specific Antigen BAK; AlphaIIb Protein; CD41 Antigen; BDPLT16; BDPLT2; ITGA2B; ITGAB; HPA3; GTA |
| Related Disease | Glanzmann Thrombasthenia 1; Bleeding Disorder, Platelet-Type 16 |
| Gene ID | 3674 |
| UniProt ID | P08514 |
| Target Overview | Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. |
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Datasheet
