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This product is an unconjugated anti-Human CD26 Monoclonal antibody (134-2C2) generated from the Mouse. This antibody can be used for FC, IF, IHC.
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specifications |
|
|---|---|
| Antibody Isotype | IgM, κ |
| Clone | 134-2C2 |
| Applications | FC; IF; IHC |
| Target | CD26 |
| Host | Mouse |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide from the amino terminal region of CD26 |
| Format | Liquid |
| Buffer | 10 mM PBS with 0.05% BSA |
| Storage | Store at 4° C. |
Target Information |
|
|---|---|
| Target Name | CD26 |
| Alternative Names | Dipeptidyl Peptidase 4; Adenosine Deaminase Complexing Protein 2; Dipeptidylpeptidase IV (CD26, Adenosine Deaminase Complexing Protein 2); T-Cell Activation Antigen CD26; Dipeptidyl Peptidase IV; ADCP-2; DPP IV; ADABP; ADCP2; DPPIV; TP103; Post-Proline Dipeptidyl Aminopeptidase IV; Xaa-Pro-Dipeptidylaminopeptidase; Gly-Pro Naphthylamidase; Dipeptidyl-Peptidase 4; Dipeptidylpeptidase 4; CD26 Antigen; DPP4 |
| Related Disease | Middle East Respiratory Syndrome; Nasopharyngitis |
| Gene ID | 1803 |
| UniProt ID | P27487 |
| Target Overview | Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones such as brain natriuretic peptide 32. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. It also acts as a receptor for human coronavirus MERS-CoV-2. |
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