Click the button below to contact us or submit your feedback about this product.
This product is a conjugated anti-Human CD160 Monoclonal antibody (BY55) generated from the Mouse. This antibody can be used for FC.
Please feel free to contact us for a quote and further discussion with our scientists. Datasheets
specifications |
|
|---|---|
| Antibody Isotype | IgM, κ |
| Clone | BY55 |
| Applications | FC |
| Target | CD160 |
| Host | Mouse |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| Species Reactivity | Human |
| Immunogen | Human NK cell line YT2C2 |
| Format | Liquid |
| Buffer | PBS with 0.2% BSA, pH 7.2 |
| Storage | Store at 4° C in dark. Do not freeze. |
Target Information |
|
|---|---|
| Target Name | CD160 |
| Alternative Names | CD160 Molecule; BY55; Natural Killer Cell Receptor BY55; NK28; NK1; Natural Killer Cell Receptor, Immunoglobulin Superfamily Member; CD160-Delta Ig |
| Related Disease | Neurotrophic Keratopathy; Cone-Rod Dystrophy 1 |
| Gene ID | 11126 |
| UniProt ID | O95971 |
| Target Overview | Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells. Receptor for both classical and non-classical MHC class I molecules. In the context of acute viral infection, recognizes HLA-C and triggers NK cell cytotoxic activity, likely playing a role in anti-viral innate immune response. On CD8+ T cells, binds HLA-A2-B2M in complex with a viral peptide and provides a costimulatory signal to activated/memory T cells. Upon persistent antigen stimulation, such as occurs during chronic viral infection, may progressively inhibit TCR signaling in memory CD8+ T cells, contributing to T cell exhaustion. On endothelial cells, recognizes HLA-G and controls angiogenesis in immune privileged sites. Receptor or ligand for TNF superfamily member TNFRSF14, participating in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. Upon ligation of TNFRSF14, provides stimulatory signal to NK cells enhancing IFNG production and anti-tumor immune response. On activated CD4+ T cells, interacts with TNFRSF14 and downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response. In the context of bacterial infection, acts as a ligand for TNFRSF14 on epithelial cells, triggering the production of antimicrobial proteins and proinflammatory cytokines. |
Click the button below to contact us or submit your feedback about this product.
KINDLY NOTE
!! For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.
!! Custom antibodies beyond the list can be tailored flexibly. Please directly Email us your specific demands.
CONTACT US
© 2024 Creative Biolabs All Rights Reserved
Datasheet
