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This product is a conjugated anti-Human ACKR4 Monoclonal antibody (674144) generated from the Mouse. This antibody can be used for FC, ELISA.
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specifications |
|
|---|---|
| Antibody Isotype | IgM |
| Clone | 674144 |
| Applications | FC; ELISA |
| Target | ACKR4 |
| Host | Mouse |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| Species Reactivity | Human |
| Immunogen | NS0 mouse myeloma cell line transfected with human CCR11 |
| Format | Liquid |
| Buffer | PBS with BSA |
| Storage | Store at 4° C in dark. Do not freeze. |
Target Information |
|
|---|---|
| Target Name | ACKR4 |
| Alternative Names | Atypical Chemokine Receptor 4; CCBP2; CCR11; VSHK1; Chemokine (C-C Motif) Receptor-Like 1; C-C Chemokine Receptor Type 11; CC Chemokine Receptor-Like 1; C-C CKR-11; CCX-CKR; CCR-11; CCRL1; PPR1; Orphan Seven-Transmembrane Receptor Chemokine Related; Chemokine Cc Motif Receptor-Like Protein 1; Chemocentryx Chemokine Receptor; CKR-11; CCR10 |
| Related Disease | Irritant Dermatitis; Sezary's Disease |
| Gene ID | 51554 |
| UniProt ID | Q9NPB9 |
| Target Overview | Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus. |
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Datasheet