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This product is an unconjugated anti-Histone H3 Monoclonal Antibody (NGE27-TT) gernerated from the mouse. This antibody can be used for applications: IB; SDS-PAGE; ELISA.
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specifications |
|
|---|---|
| Antibody Isotype | IgE, κ |
| Clone | NGE27-TT |
| Applications | IB; SDS-PAGE; ELISA |
| Target | Histone H3 |
| Host | Mouse |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| Species Reactivity | Bovine, Mouse |
| Immunogen | Produced by hybridoma cells line using spleen cells derived from NC/Nga mice with spontaneously develop severe atopic-like dermatitis and a strong associated serum IgE response. |
| Format | Liquid |
| Buffer | PBS |
| Storage | Store at 4°C for short-term and -20°C for long-term. Avoid repeated freeze-thaw cycles. |
Target Information |
|
|---|---|
| Target Name | Histone H3 |
| Alternative Names | Histone H3.1, Histone H3.2, Histone H3.3 |
| Related Disease | Allergy |
| Target Overview | Histone H3 is one of the five main histones involved in the structure of chromatin in eukaryotic cells. Histone H3.1: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histone H3.2: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histone H3.3: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
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Datasheet
