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This product is an unconjugated anti-GAPDH Monoclonal antibody (1D4) generated from the Mouse. This antibody can be used for WB, ChIP, IF, IHC, IP.
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specifications |
|
|---|---|
| Antibody Isotype | IgM |
| Clone | 1D4 |
| Applications | WB; ChIP; IF; IHC; IP |
| Target | GAPDH |
| Host | Mouse |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| Species Reactivity | Porcine, Human, Mouse, Rat, Avian, Bovine, Canine, Chicken |
| Immunogen | Purified porcine GAPDH |
| Format | Liquid |
| Buffer | 50% PBS with 50% Glycerol |
| Storage | Store at 4° C for short term and at -20° C or lower for long term. Avoid freeze-thaw cycles. |
Target Information |
|
|---|---|
| Target Name | GAPDH |
| Alternative Names | Glyceraldehyde-3-Phosphate Dehydrogenase; Peptidyl-Cysteine S-Nitrosylase GAPDH; GAPD; Epididymis Secretory Sperm Binding Protein Li 162eP; Oct1 Coactivator In S Phase, 38 Kd Component; Aging-Associated Gene 9 Protein; OCAS, P38 Component; HEL-S-162eP; G3PD |
| Related Disease | Aging; Schistosomiasis |
| Gene ID | 396823 |
| UniProt ID | P00355 |
| Target Overview | Glyceraldehyde-3-Phosphate Dehydrogenase has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. |
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Datasheet
