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Mouse Anti-CFTR Monoclonal Antibody (CF3)

Mouse Anti-CFTR Monoclonal Antibody (CF3) (CAT#: NGM-016)

This product is an unconjugated anti-CFTR Monoclonal antibody (CF3) generated from the Mouse. This antibody can be used for WB, FC, IF, IHC, IP, Block.

Please feel free to contact us for a quote and further discussion with our scientists. Datasheets

specifications
Antibody Isotype IgM
Clone CF3
Applications WB; FC; IF; IHC; IP; Block
Target CFTR
Host Mouse
Clonality Monoclonal
Antibody Type Primary antibody
species Reactivity Human, Mouse, Rat, Chicken
Immunogen Recombinant human cystic fibrosis transmembrane conductance regulator, aa., GRIIASYDPDNKEER
Format Liquid
Buffer Ascites diluted with PBS
Storage Store at -20° C to -80° C. Avoid freeze-thaw cycles.
Target Information
Target Name CFTR
Alternative Names CF Transmembrane Conductance Regulator; Cystic Fibrosis Transmembrane Conductance Regulator; Channel Conductance-Controlling ATPase; CAMP-Dependent Chloride Channel; CFTR/MRP; TNR-CFTR; MRP7; Cystic Fibrosis Transmembrane Conductance Regulating 3; ATP-Binding Cassette Sub-Family C Member 7
Gene ID 1080
UniProt ID P13569
Target Overview CF Transmembrane Conductance Regulator is an epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Plays an important role in airway fluid homeostasis. Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. Inhibits the activity of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G. Inhibits the activity of the ENaC channel containing subunits SCNN1D, SCNN1B and SCNN1G, but not of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.

KINDLY NOTE
!! For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.

!! Custom antibodies beyond the list can be tailored flexibly. Please directly Email us your specific demands.

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For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.

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