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This product is an unconjugated anti-ATG12 Monoclonal Antibody (NGE17-TT) gernerated from the mouse. This antibody can be used for applications: IF; IHC; WB.
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specifications |
|
|---|---|
| Antibody Isotype | IgE |
| Clone | NGE17-TT |
| Applications | IF; IHC; WB |
| Target | ATG12 |
| Host | Mouse |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide corresponding to C terminal of Human Atg12 |
| Format | Liquid |
| Buffer | TBS, pH 7.4, with 1% BSA, 40% Glycerol |
| Storage | Store at 4°C for short-term and -20°C for long-term. Avoid repeated freeze-thaw cycles. |
Target Information |
|
|---|---|
| Target Name | ATG12 |
| Alternative Names | Autophagy Related 12; APG12; Ubiquitin-Like Protein ATG12; APG12 Autophagy 12-Like; APG12L; ATG12 Autophagy Related 12 Homolog (S. Cerevisiae); Apg12 (Autophagy 12, S. Cerevisiae)-Like; APG12 Autophagy 12-Like (S. Cerevisiae); ATG12 Autophagy Related 12 Homolog; Apg12 (Autophagy, Yeast) Homolog; Autophagy-Related Protein 12; APG12-Like; HAPG12; FBR93 |
| Related Disease | Stomatitis; Macular Degeneration Age-Related 14 |
| Gene ID | 9140 |
| UniProt ID | O94817 |
| Target Overview | Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. (Microbial infection) May act as a proviral factor. In association with ATG5, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection. Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for the initiation of HCV replication, but not required once infection is established. |
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Datasheet
