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Mouse anti-ATG12 IgE Monoclonal Antibody (NGE17-TT) (CAT#: NGE-044)

This product is an unconjugated anti-ATG12 Monoclonal Antibody (NGE17-TT) gernerated from the mouse. This antibody can be used for applications: IF; IHC; WB.

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Antibody Isotype IgE
Clone NGE17-TT
Applications IF; IHC; WB
Target ATG12
Host Mouse
Clonality Monoclonal
Antibody Type Primary antibody
Species Reactivity Human, Mouse, Rat
Immunogen Synthetic peptide corresponding to C terminal of Human Atg12
Format Liquid
Buffer TBS, pH 7.4, with 1% BSA, 40% Glycerol
Storage Store at 4°C for short-term and -20°C for long-term. Avoid repeated freeze-thaw cycles.

Target Information

Target Name ATG12
Alternative Names Autophagy Related 12; APG12; Ubiquitin-Like Protein ATG12; APG12 Autophagy 12-Like; APG12L; ATG12 Autophagy Related 12 Homolog (S. Cerevisiae); Apg12 (Autophagy 12, S. Cerevisiae)-Like; APG12 Autophagy 12-Like (S. Cerevisiae); ATG12 Autophagy Related 12 Homolog; Apg12 (Autophagy, Yeast) Homolog; Autophagy-Related Protein 12; APG12-Like; HAPG12; FBR93
Related Disease Stomatitis; Macular Degeneration Age-Related 14
Gene ID 9140
UniProt ID O94817
Target Overview Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes.
(Microbial infection) May act as a proviral factor. In association with ATG5, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection. Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for the initiation of HCV replication, but not required once infection is established.
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For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.






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