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IgM Antibody Application for Vaccine Development

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Creative Biolabs is a leading service provider that focuses on antibody development. Currently, various platforms have been established for analyzing the function and mechanism of action of antibodies. By combining cutting edge technologies with proprietary innovations, our scientists can provide a full range of services on IgM antibody development. Meanwhile, we can provide IgM antibodies of different species to meet any requirement of vaccine development.

IgM Antibody Application for Disease Therapy

Immunoglobulin M (IgM) plays an important role in mediating immune responses from infections. In general, IgM can regulate the immune homeostasis, prevent the overreaction of inflammatory responses in a wide variety of autoimmune diseases. More recent reports have demonstrated that nature IgM can restrict the growth of a number of microbial pathogens by neutralizing and activating the classical complement pathway. Meanwhile, IgM can recognize specific pathogens by a type of dendritic cells (DCs) and induce the polarization of T-cell responses. Taken together, these results have indicated that complexes of antigenic ligands with IgM could be used to explain the mechanism by which alum adjuvant-containing vaccines enhances humoral immunity. In addition, recent research has highlighted that IgM is an attractive candidate for developing a monoclonal antibody (mAb) or vaccines against a number of disease-associated targets.

 Natural IgM in immune equilibrium.Fig.1 Natural IgM in immune equilibrium. (Kaveri, 2012)

The Application of IgM Antibody in Vaccine Development

Vaccines effectively prevent diseases by stimulating the immune system and maintaining the immune response, thereby eradicating pathogens and diseased cells. Good immune-stimulatory vaccine adjuvants activate DCs directly or through Toll-like receptor (TLR) proteins found in different subsets of dendritic cells. IgM is another component of the innate immune system, which shares similar properties to TLRs, but with broader specificity and fewer complications in activating an inflammatory response. It has some auxiliary costimulatory properties. Studies have shown that both antigen and exogenous antigen-specific IgM can produce enhanced antibody responses in the process of antibody-mediated feedback regulation. In addition, IgM Fc receptors were found in B lymphocyte and T lymphocyte, suggesting that these two adaptive immune responses may be caused by the direct interaction between IgM and its Fc receptor. Therefore, IgM can be used as a dual-purpose therapeutic drug, as a passive immunotherapeutic agent or vaccine antigen carrier, and as a vaccine adjuvant, which can be used for both immediate treatment and long-term prevention.

Our Services for Vaccine Development

Researchers have illustrated that IgM is associated with several types of vaccine development, such as Duck embryo vaccine (DEV) and human immunodeficiency virus (HIV) vaccine. It has been proved that IgM plays a critical role in neutralizing antibody responses to bacteria, and multiple doses of DEV and simple vaccine can prolong the immune response of IgM in animals immunized. Furthermore, a new study conducted on HIV vaccine has suggested that IgM can block the HIV transmission and delay the progression of the disease in vivo as well as widely used in anti-HIV vaccine development. At present, Creative Biolabs offers a number of IgM antibodies of different species to meet any requirement for vaccine development. Furthermore, we also provide a panel of vaccine development services based on IgM, which includes but are not limited to:

  • Live attenuated and virus-like particles vaccine design
  • Vaccine target validation
  • Development of vaccine delivery system
  • The immunogenicity and safety evaluation of vaccine
  • Cell-based vaccines

Equipped with our advanced technologies and platforms, Creative Biolabs now provide the non-IgG therapeutic antibodies products against a variety of diseases. We are always dedicated to assisting our clients with the most satisfactory non-IgG antibody related services. If you are interested in our services, please do not hesitate to contact us for more details.

Reference

  1. Kaveri, S. V., et al. Natural IgM in immune equilibrium and harnessing their therapeutic potential. J Immunol. 2012, 188(3): 939-945.

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!! For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.

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For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.

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