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Anti-Human TNF-α IgA Monoclonal Antibody (NGA16M-TT) (CAT#: NGA-066)

This product is an unconjugated anti-human TNF-α monoclonal antibody gernerated from the mouse. This antibody can be used for applications: ELISA, Flow Cytometry/FACS.

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Antibody Isotype IgA
Clone NGA16M-TT
Applications ELISA; FC
Target TNF-α
Host Mouse
Clonality Monoclonal
Antibody Type Primary antibody
Species Reactivity Human
Immunogen Purified recombinant human TNF
Format Liquid
Buffer PBS
Storage Store at 4°C for short-term and -20°C for long-term. Avoid repeated freeze-thaw cycles.

Target Information

Target Name TNF-α
Alternative Names Tumor Necrosis Factor; TNF-Alpha; TNFSF2; Tumor Necrosis Factor Ligand Superfamily Member 2; TNFA; DIF; Tumor Necrosis Factor Ligand 1F; Tumor Necrosis Factor-Alpha; TNF Superfamily Member 2; APC1 Protein; Cachectin; TNLG1F; TNF
Related Disease Asthma; Malaria
Gene ID 7124
UniProt ID P01375
Target Overview Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective. Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance.
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For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.






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