CLOSE
SEARCH FOR
Book a Meeting
Anti-Human TNF-α IgA Monoclonal Antibody (NGA16M-TT) (CAT#: NGA-066)

This product is an unconjugated anti-human TNF-α monoclonal antibody gernerated from the mouse. This antibody can be used for applications: ELISA, Flow Cytometry/FACS.

Please feel free to contact us for a quote and further discussion with our scientists. Datasheets

specifications

Antibody Isotype IgA
Clone NGA16M-TT
Applications ELISA; FC
Target TNF-α
Host Mouse
Clonality Monoclonal
Antibody Type Primary antibody
Species Reactivity Human
Immunogen Purified recombinant human TNF
Format Liquid
Buffer PBS
Storage Store at 4°C for short-term and -20°C for long-term. Avoid repeated freeze-thaw cycles.

Target Information

Target Name TNF-α
Alternative Names Tumor Necrosis Factor; TNF-Alpha; TNFSF2; Tumor Necrosis Factor Ligand Superfamily Member 2; TNFA; DIF; Tumor Necrosis Factor Ligand 1F; Tumor Necrosis Factor-Alpha; TNF Superfamily Member 2; APC1 Protein; Cachectin; TNLG1F; TNF
Related Disease Asthma; Malaria
Gene ID 7124
UniProt ID P01375
Target Overview Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective. Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance.
  • Customer Reviews
  • Downloadable Resources

Click the button below to contact us or submit your feedback about this product.

KINDLY NOTE
!! For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.

!! Custom antibodies beyond the list can be tailored flexibly. Please directly Email us your specific demands.

Online Inquiry
For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.

CONTACT US

USA

Tel:

Fax:

Email:

Stay Up To Date
Subscribe

© 2024 Creative Biolabs All Rights Reserved