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Anti-Human SNX6 IgA Monoclonal Antibody (SNX6-76) (CAT#: NGA-096)

This product is a recombinant unconjugated anti-human SNX6 monoclonal antibody gernerated by Hybridoma technology. This antibody can be used for applications: Western Blotting, ELISA.

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Antibody Isotype IgA
Clone SNX6-76
Applications WB; ELISA
Target SNX6
Clonality Monoclonal
Antibody Type Primary antibody
Species Reactivity Rat, Human, Bovine, Mouse
Format Liquid
Buffer 10 mM PBS, pH 7.4
Storage Store at -20°C. Avoid repeated freeze-thaw cycles.

Target Information

Target Name SNX6
Alternative Names Sorting Nexin 6; TRAF4-Associated Factor 2; Sorting Nexin-6; Tumor Necrosis Factor Receptor-Associated Factor 4(TRAF4)-Associated Factor 2; MSTP010; TFAF2
Related Disease Holoprosencephaly 8; Chromosome 14Q11-Q22 Deletion Syndrome
Gene ID 58533
UniProt ID Q9UNH7
Target Overview Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Does not have in vitro vesicle-to-membrane remodeling activity. Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R. May function as link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network. Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation. In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B. May contribute to transcription regulation.
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For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.






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