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This product is a recombinant unconjugated anti-human SNX6 monoclonal antibody gernerated by Hybridoma technology. This antibody can be used for applications: Western Blotting, ELISA.
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specifications |
|
|---|---|
| Antibody Isotype | IgA |
| Clone | SNX6-76 |
| Applications | WB; ELISA |
| Target | SNX6 |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| Species Reactivity | Rat, Human, Bovine, Mouse |
| Format | Liquid |
| Buffer | 10 mM PBS, pH 7.4 |
| Storage | Store at -20°C. Avoid repeated freeze-thaw cycles. |
Target Information |
|
|---|---|
| Target Name | SNX6 |
| Alternative Names | Sorting Nexin 6; TRAF4-Associated Factor 2; Sorting Nexin-6; Tumor Necrosis Factor Receptor-Associated Factor 4(TRAF4)-Associated Factor 2; MSTP010; TFAF2 |
| Related Disease | Holoprosencephaly 8; Chromosome 14Q11-Q22 Deletion Syndrome |
| Gene ID | 58533 |
| UniProt ID | Q9UNH7 |
| Target Overview | Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Does not have in vitro vesicle-to-membrane remodeling activity. Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R. May function as link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network. Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation. In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B. May contribute to transcription regulation. |
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Datasheet
