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This product is an unconjugated anti-human PTK2B monoclonal antibody gernerated from the mouse. This antibody can be used for applications: Western Blotting, ELISA.
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specifications |
|
|---|---|
| Antibody Isotype | IgG IgA IgM Mix Lambda |
| Clone | 3G2 |
| Applications | WB; ELISA |
| Target | PTK2B |
| Host | Mouse |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| Species Reactivity | Human |
| Immunogen | PTK2B (aa 682-871) partial recombinant protein with GST tag. |
| Format | Liquid |
| Buffer | Ascites fluid |
| Storage | Store at -20°C. Avoid repeated freeze-thaw cycles. |
Target Information |
|
|---|---|
| Target Name | PTK2B |
| Alternative Names | Protein Tyrosine Kinase 2 Beta; CADTK; RAFTK; FAK2; CAKB; PYK2; Calcium-Regulated Non-Receptor Proline-Rich Tyrosine Kinase; Related Adhesion Focal Tyrosine Kinase; Calcium-Dependent Tyrosine Kinase; Protein-Tyrosine Kinase 2-Beta; Proline-Rich Tyrosine Kinase 2; Cell Adhesion Kinase Beta; Focal Adhesion Kinase 2; CAK-Beta; FADK 2; PTK; PTK2B Protein Tyrosine Kinase 2 Beta; Protein Kinase B; FADK2; PKB |
| Related Disease | Osteoporosis; Osteopetrosis |
| Gene ID | 2185 |
| UniProt ID | Q14289 |
| Target Overview | Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca2+ levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. |
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