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This product is an unconjugated anti-human MPO monoclonal antibody gernerated from the mouse. This antibody can be used for applications: Western Blotting, Immunohistochemistry, Immunofluorescence, ELISA.
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specifications |
|
|---|---|
| Antibody Isotype | IgA |
| Clone | 4C11F6 |
| Applications | WB; IHC; IF; ELISA |
| Target | Myeloperoxidase |
| Host | Mouse |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| Species Reactivity | Human |
| Immunogen | MPO fusion protein |
| Format | Liquid |
| Buffer | PBS with 50% glycerol pH 7.3 |
| Storage | Store at -20°C. |
Target Information |
|
|---|---|
| Target Name | Myeloperoxidase |
| Alternative Names | MPO |
| Related Disease | Myeloperoxidase Deficiency; Alzheimer Disease |
| Gene ID | 4353 |
| UniProt ID | P05164 |
| Target Overview | Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. The MPO gene encodes myeloperoxidase, a lysosomal hemoprotein located in the azurophilic granules of polymorphonuclear (PMN) leukocytes and monocytes. In response to stimulation, MPO is activated into a transient intermediate with potent antimicrobial oxidizing abilities(PMID:17650507). The mRNA is translated into a single protein of 90 kDa, which displays enzymatic activity and undergoes proteolytic maturation into a heavy chain of 59 kDa and a light chain of 13.5 kDa; these subunits then dimerize into the mature tetramer and the mature MPO is a heterotetramer composed of two identical heavy chains and two identical light chains(PMID:12773517). The 24-kDa material had a map identical to that of 13.5 kDa subunit and represents a dimer of the 13.5 kDa subunit (PMID:3008892). Defects in MPO are the cause of myeloperoxidase deficiency (MPOD). It has 3 isoforms produced by alternative splicing. |
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Datasheet