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This product is an unconjugated anti-human KEAP1 monoclonal antibody gernerated from the mouse. This antibody can be used for applications: Western Blotting, Immunohistochemistry, Immunofluorescence, ELISA.
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specifications |
|
|---|---|
| Antibody Isotype | IgA |
| Clone | 4G10H9 |
| Applications | WB; IHC; IF; ELISA |
| Target | KEAP1 |
| Host | Mouse |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| Species Reactivity | Human, Rat, Mouse |
| Immunogen | KEAP1 fusion protein |
| Format | Liquid |
| Buffer | PBS with 50% glycerol, pH7.3 |
| Storage | Store at -20°C. |
Target Information |
|
|---|---|
| Target Name | KEAP1 |
| Alternative Names | Kelch Like ECH Associated Protein 1; KLHL19; INrf2; Kelch-Like ECH-Associated Protein 1; Kelch-Like Family Member 19; Cytosolic Inhibitor Of Nrf2; Kelch-Like Protein 19; KIAA0132; KEAP1 Delta C; INRF2 |
| Related Disease | Goiter Multinodular 1 With Or Without Sertoli-Leydig Cell Tumors; Papillary Adenocarcinoma |
| Gene ID | 9817 |
| UniProt ID | Q14145 |
| Target Overview | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes. In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2. The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62, increasing SQSTM1/p62 sequestering activity and degradation. The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome. |
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Datasheet
