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This product is an unconjugated anti-human Gelsolin monoclonal antibody gernerated from the mouse. This antibody can be used for applications: Western Blotting, Immunohistochemistry, ELISA.
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specifications |
|
|---|---|
| Antibody Isotype | IgA |
| Clone | 3C4A2 |
| Applications | WB; IHC; ELISA |
| Target | Gelsolin |
| Host | Mouse |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| Species Reactivity | Human |
| Immunogen | Gelsolin fusion protein |
| Format | Liquid |
| Buffer | PBS with 50% glycerol pH 7.3 |
| Storage | Store at -20°C. |
Target Information |
|
|---|---|
| Target Name | Gelsolin |
| Alternative Names | Actin-Depolymerizing Factor; Brevin; AGEL; ADF; Epididymis Secretory Sperm Binding Protein; Gelsolin (Amyloidosis, Finnish Type); Amyloidosis, Finnish Type; DKFZp313L0718; GSN |
| Related Disease | Amyloidosis Finnish Type; Lattice Corneal Dystrophy Type Ii |
| Gene ID | 2934 |
| UniProt ID | P06396 |
| Target Overview | Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. Gelsolin (GSN) is an actin binding protein that regulates actin-severing/depolymerizing in a calcium dependent manner, and acts as a multifunctional regulator for cell metabolism and survival. Gelsolin exists in two isoforms: a cytoplasmic gelsolin (cGSN; 80-90 kDa) and a plasma gelsolin (pGSN; 93 kDa), differing at N terminal residues. Decreased levels of pGSN are strongly associated with human diseases, such as, acute liver injury, major trauma, myocardial infarction, inflammation, lung injury, rheumatoid arthritis, hemodialysis, multiple sclerosis, Alzheimer's disease. |
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Datasheet