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Anti-Human Gelsolin IgA Monoclonal Antibody (3C4A2) (CAT#: NGA-081)

This product is an unconjugated anti-human Gelsolin monoclonal antibody gernerated from the mouse. This antibody can be used for applications: Western Blotting, Immunohistochemistry, ELISA.

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Antibody Isotype IgA
Clone 3C4A2
Applications WB; IHC; ELISA
Target Gelsolin
Host Mouse
Clonality Monoclonal
Antibody Type Primary antibody
Species Reactivity Human
Immunogen Gelsolin fusion protein
Format Liquid
Buffer PBS with 50% glycerol pH 7.3
Storage Store at -20°C.

Target Information

Target Name Gelsolin
Alternative Names Actin-Depolymerizing Factor; Brevin; AGEL; ADF; Epididymis Secretory Sperm Binding Protein; Gelsolin (Amyloidosis, Finnish Type); Amyloidosis, Finnish Type; DKFZp313L0718; GSN
Related Disease Amyloidosis Finnish Type; Lattice Corneal Dystrophy Type Ii
Gene ID 2934
UniProt ID P06396
Target Overview Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
Gelsolin (GSN) is an actin binding protein that regulates actin-severing/depolymerizing in a calcium dependent manner, and acts as a multifunctional regulator for cell metabolism and survival. Gelsolin exists in two isoforms: a cytoplasmic gelsolin (cGSN; 80-90 kDa) and a plasma gelsolin (pGSN; 93 kDa), differing at N terminal residues. Decreased levels of pGSN are strongly associated with human diseases, such as, acute liver injury, major trauma, myocardial infarction, inflammation, lung injury, rheumatoid arthritis, hemodialysis, multiple sclerosis, Alzheimer's disease.
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For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.






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