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This product is an unconjugated anti-human Fibrinopeptide A monoclonal antibody gernerated from the mouse. This antibody can be used for applications: Western Blotting, ELISA, Immunohistochemistry, Immunohistochemistry.
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specifications |
|
|---|---|
| Antibody Isotype | IgA |
| Clone | 1-A7 |
| Applications | WB; ELISA; IHC; IHC |
| Target | Fibrinogen alpha chain |
| Host | Mouse |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| Species Reactivity | Human |
| Immunogen | Full length Fibrinopeptide A |
| Format | Liquid |
| Buffer | TBS, pH7.4, 1% BSA, 40% Glycerol |
| Storage | Store at 4°C for short-term and -20°C for long-term. Avoid repeated freeze-thaw cycles. |
Target Information |
|
|---|---|
| Target Name | Fibrinogen alpha chain |
| Alternative Names | FGA; Fib2; Fibrinogen A; Fibrinogen alpha subunit; fibrinogen, A alpha polypeptide; FPA |
| Related Disease | Dysfibrinogenemia Congenital; Afibrinogenemia Congenital |
| Gene ID | 2243 |
| UniProt ID | P02671 |
| Target Overview | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. |
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Datasheet
