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This product is an unconjugated anti-human ATP2B4 monoclonal antibody gernerated from the mouse. This antibody can be used for applications: Western Blotting, ELISA.
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specifications |
|
|---|---|
| Antibody Isotype | IgG IgA IgM Mix Lambda |
| Clone | 2C7 |
| Applications | WB; ELISA |
| Target | ATP2B4 |
| Host | Mouse |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| Species Reactivity | Human |
| Immunogen | ATP2B4 ( aa 1- 92) partial recombinant protein with GST tag. |
| Format | Liquid |
| Buffer | Ascites fluid |
| Storage | Store at -20°C. Avoid repeated freeze-thaw cycles. |
Target Information |
|
|---|---|
| Target Name | ATP2B4 |
| Alternative Names | ATPase Plasma Membrane Ca2+ Transporting 4; Plasma Membrane Calcium-Transporting ATPase 4; PMCA4; ATPase Ca++ Transporting, Plasma Membrane 4; Matrix-Remodeling-Associated Protein 1; ATP2B2; MXRA1; Plasma Membrane Calcium ATPase Isoform 4; Plasma Membrane Calcium Pump Isoform 4; Matrix-Remodelling Associated 1; Sarcolemmal Calcium Pump; PMCA4b; PMCA4x |
| Related Disease | X-Linked Cerebellar Ataxia; Malaria |
| Gene ID | 493 |
| UniProt ID | P23634 |
| Target Overview | Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility. The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified. |
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Datasheet
