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Anti-Human ATP2B4 IgA Monoclonal Antibody (2C7) (CAT#: NGA-090)

This product is an unconjugated anti-human ATP2B4 monoclonal antibody gernerated from the mouse. This antibody can be used for applications: Western Blotting, ELISA.

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Antibody Isotype IgG IgA IgM Mix Lambda
Clone 2C7
Applications WB; ELISA
Target ATP2B4
Host Mouse
Clonality Monoclonal
Antibody Type Primary antibody
Species Reactivity Human
Immunogen ATP2B4 ( aa 1- 92) partial recombinant protein with GST tag.
Format Liquid
Buffer Ascites fluid
Storage Store at -20°C. Avoid repeated freeze-thaw cycles.

Target Information

Target Name ATP2B4
Alternative Names ATPase Plasma Membrane Ca2+ Transporting 4; Plasma Membrane Calcium-Transporting ATPase 4; PMCA4; ATPase Ca++ Transporting, Plasma Membrane 4; Matrix-Remodeling-Associated Protein 1; ATP2B2; MXRA1; Plasma Membrane Calcium ATPase Isoform 4; Plasma Membrane Calcium Pump Isoform 4; Matrix-Remodelling Associated 1; Sarcolemmal Calcium Pump; PMCA4b; PMCA4x
Related Disease X-Linked Cerebellar Ataxia; Malaria
Gene ID 493
UniProt ID P23634
Target Overview Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility.
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified.
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For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.






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