IgA, also known as immunoglobulin A, is the main antibody at the surface of mucosal that plays a critical role in regulating the immune response. In general, IgA consists of two subtypes, IgA1 and IgA2. IgA2 has a longer amino-acid hinge region than IgA1, and IgA1 is the most abundant isotype in plasma, bone marrow and spleen. IgA has three isoforms, including monomeric, dimeric and secretory forms. The dimeric and secretory form of IgA can be usually found at mucosal surfaces. Monomeric and dimeric IgA are prone to bind to the IgA receptor.
Decade studies have demonstrated that IgA is an important factor in mediating the inflammatory responses in humans or mammal animals. It can inhibit or activate the release of inflammatory-associated elements by interacting with a wide variety of receptors. Meanwhile, recent research has revealed that the IgA Fc receptor FcαRI (CD89) might be a powerful tool in the anti-inflammatory effect. Moreover, IgA monoclonal antibodies (mAbs) can be beneficial and potential in the treatment of various cancers and other related immune immunological diseases.
Creative Biolabs is a professional non-IgG therapeutic antibody development expert with extensive experience in antibody design, immunogenicity evaluation, safety evaluation, and production process optimization. We have won a good reputation among our worldwide customers for successfully accomplishing numerous challenging projects in IgA antibody development. Here, we provide a number of premade IgA monoclonal and polyclonal antibodies with high purity and quality. If the IgA antibodies you need are not in our list, we also provide customization services for your specific antibody products. Please directly contact us or send us an inquiry for more detailed information.
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