Introduction: The Rise of IgY Antibodies in Therapeutic Research In recent years, the biopharmaceutical industry has witnessed a paradigm shift toward exploring alternative antibody formats beyond conventional IgG molecules. Among these, immunoglobulinRead More…
HIF-1α: Orchestrating Metabolic Rewiring for IgA Synthesis The hypoxic microenvironment of germinal centers (GCs) is a critical niche where B cells undergo clonal expansion and antibody diversification. Central to this process isRead More…
Allergic diseases, affecting over 300 million people globally, are characterized by dysregulated immune responses to harmless antigens. Central to this pathology is the high-affinity IgE receptor (FcεRI), a multimeric complex that orchestratesRead More…
Immunosensors are rapidly gaining traction in various diagnostic fields due to their high sensitivity and specificity. Among these, IgA antibodies have emerged as critical components in the development of advanced biosensors, particularlyRead More…
The complex interplay of immunoglobulins—IgE, IgG, and IgA—underpins the mechanisms of allergic diseases. These antibodies not only directly regulate allergic reactions but also play a crucial role in inducing immune tolerance throughRead More…
Introduction COVID-19, caused by the SARS-CoV-2 virus, has become a global health crisis since its emergence in late 2019. The severity of COVID-19 can vary widely among patients, ranging from asymptomatic orRead More…
Introduction Childhood IgA vasculitis, previously known as Henoch-Schönlein purpura, is a prevalent autoimmune disorder affecting small blood vessels, predominantly in children. This condition manifests through distinctive symptoms such as skin purpura, jointRead More…
Allergic diseases, including asthma, allergic rhinitis, atopic dermatitis, and chronic urticaria, now affect more than 25-30% of the global population, with incidence rates continuing to rise. This growing prevalence places a significantRead More…
In the intricate and sophisticated human immune system, Immunoglobulin M (IgM) plays a pivotal role as the first line of defense against pathogens. Known for its large molecular weight and unique properties,Read More…
Introduction Immunoglobulin A (IgA) antibodies are essential components of mucosal immunity, playing a crucial role in pathogen defense at the body’s surfaces, including respiratory and gastrointestinal tracts. With recent breakthroughs, IgA antibodiesRead More…