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This product is an unconjugated anti-Mouse CD45 Monoclonal antibody (GL24) generated from the Rat. This antibody can be used for FC, IP.
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specifications |
|
|---|---|
| Antibody Isotype | IgM, κ |
| Clone | GL24 |
| Applications | FC; IP |
| Target | CD45 |
| Epitope | This antibody recognizes an exon C-dependent epitope of CD45 glycoprotein. |
| Host | Rat |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| Species Reactivity | Mouse |
| Immunogen | Activated DBA/2 B cells |
| Format | Liquid |
| Buffer | 0.1M BBS, pH 8.2 |
| Storage | Store at 4° C. |
Target Information |
|
|---|---|
| Target Name | CD45 |
| Alternative Names | Protein Tyrosine Phosphatase Receptor Type C; T200; Receptor-Type Tyrosine-Protein Phosphatase C; CD45 Antigen; GP180; L-CA; LCA; Protein Tyrosine Phosphatase, Receptor Type, C Polypeptide; T200 Leukocyte Common Antigen; Leukocyte Common Antigen; T200 Glycoprotein; CD45R; PTPRC; B220; LY5 |
| Related Disease | Severe Combined Immunodeficiency Autosomal Recessive T Cell-Negative B Cell-Positive Nk Cell-Positive; Hepatitis C Virus |
| Gene ID | 5788 |
| UniProt ID | P06800 |
| Target Overview | Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. I acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation. |
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Datasheet