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This product is an unconjugated anti-Piccolo Monoclonal antibody (4G3.3) generated from the Mouse. This antibody can be used for WB, IHC.
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specifications |
|
|---|---|
| Antibody Isotype | IgM, κ |
| Clone | 4G3.3 |
| Applications | WB; IHC |
| Target | Piccolo |
| Host | Mouse |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| Species Reactivity | Mouse, Rat |
| Immunogen | GST-tagged recombinant protein |
| Format | Liquid |
| Buffer | PBS |
| Storage | Store at 4° C. |
Target Information |
|
|---|---|
| Target Name | Piccolo |
| Alternative Names | Piccolo Presynaptic Cytomatrix Protein; Aczonin; ACZ; Protein Piccolo; KIAA0559; Piccolo (Presynaptic Cytomatrix Protein); DKFZp779G1236; PCH3; PCLO |
| Related Disease | Pontocerebellar Hypoplasia Type 3; Pontocerebellar Hypoplasia |
| Gene ID | 26875 |
| UniProt ID | Q9QYX7 |
| Target Overview | Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released. After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts. At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis. Organizes as well the readily releasable pool of synaptic vesicles and safeguards a fraction of them to be not immediately available for action potential-induced release. Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy. Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import. |
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Datasheet