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This product is an unconjugated anti-Neurotoxin type A Monoclonal antibody (A33) generated from the Mouse. This antibody can be used for WB, ELISA.
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specifications |
|
|---|---|
| Antibody Isotype | IgM |
| Clone | A33 |
| Applications | WB; ELISA |
| Target | Neurotoxin type A |
| Host | Mouse |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| Species Reactivity | Clostridium Botulinum |
| Immunogen | C. botulinum toxin A heavy chain, aa., 869-887 |
| Format | Liquid |
| Buffer | PBS, pH 7.4 |
| Storage | Store at 4° C. |
Target Information |
|
|---|---|
| Target Name | Neurotoxin type A |
| Alternative Names | Botulinum neurotoxin type A; BoNT/A; Bontoxilysin-A |
| Related Disease | Botulism; flaccid paralysis |
| Gene ID | 56879027 |
| UniProt ID | P0DPI1 |
| Target Overview | Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of the eukaryotic host skeletal and autonomic nervous system, with frequent heart or respiratory failure. Precursor of botulinum neurotoxin A which has 2 coreceptors; complex polysialylated gangliosides found on neural tissue and specific membrane-anchored proteins of synaptic vesicles. Receptor proteins are exposed on host presynaptic cell membrane during neurotransmitter release, when the toxin heavy chain (HC) binds to them. Upon synaptic vesicle recycling the toxin is taken up via the endocytic pathway. When the pH of the toxin-containing endosome drops a structural rearrangement occurs so that the N-terminus of the HC forms pores that allows the light chain (LC) to translocate into the cytosol. Once in the cytosol the disulfide bond linking the 2 subunits is reduced and LC cleaves its target protein on synaptic vesicles, preventing their fusion with the cytoplasmic membrane and thus neurotransmitter release. |
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Datasheet