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Mouse Anti-Human S100A8 IgM Monoclonal Antibody (7C12/4) (CAT#: NGM-276)

This product is an unconjugated anti-Human S100A8 Monoclonal antibody (7C12/4) generated from the Mouse. This antibody can be used for WB, ELISA, FC, IHC, Block.

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specifications

Antibody Isotype IgM
Clone 7C12/4
Applications WB; ELISA; FC; IHC; Block
Target S100A8
Host Mouse
Clonality Monoclonal
Antibody Type Primary antibody
Species Reactivity Human
Immunogen Recombinant human S100A8
Format Liquid
Buffer PBS
Storage Store at 4° C.

Target Information

Target Name S100A8
Alternative Names S100 Calcium Binding Protein A8; MRP8; Migration Inhibitory Factor-Related Protein 8; Leukocyte L1 Complex Light Chain; Urinary Stone Protein Band A; Calprotectin L1L Subunit; Cystic Fibrosis Antigen; Protein S100-A8; Calgranulin A; 60B8AG; CAGA; CFAG; CGLA; S100 Calcium-Binding Protein A8 (Calgranulin A); S100 Calcium-Binding Protein A8; CP-10; MA387; MRP-8; L1Ag; MIF
Related Disease eptic Ulcer Disease; Duodenal Ulcer
Gene ID 6279
UniProt ID P05109
Target Overview S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread. The iNOS-S100A8/A9 transnitrosylase complex directs selective inflammatory stimulus-dependent S-nitrosylation of GAPDH and probably multiple targets such as ANXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif; S100A8 seems to contribute to S-nitrosylation site selectivity.
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!! For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.

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