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Mouse Anti-Human Presenilin-2 Monoclonal Antibody (198C679.2.)

Mouse Anti-Human Presenilin-2 Monoclonal Antibody (198C679.2.) (CAT#: NGM-200)

This product is an unconjugated anti-Human Presenilin-2 Monoclonal antibody (198C679.2.) generated from the Mouse. This antibody can be used for WB.

Please feel free to contact us for a quote and further discussion with our scientists. Datasheets

specifications
Antibody Isotype IgM
Clone 198C679.2.
Applications WB
Target Presenilin-2
Host Mouse
Clonality Monoclonal
Antibody Type Primary antibody
species Reactivity Human
Immunogen Recombinant partial human Presenilin-2
Format Liquid
Buffer Tissue culture supernatant
Storage Store at 4° C for short term and at -20° C or lower for long term. Avoid freeze-thaw cycles.
Target Information
Target Name Presenilin-2
Alternative Names STM2; PS2; Presenilin-2; AD3LP; STM-2; AD3L; E5-1; PS-2; CMD1V; PSEN2; PSNL2
Related Disease Alzheimer Disease 4; Cardiomyopathy Dilated 1V
Gene ID 5664
UniProt ID P49810
Target Overview Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria.

KINDLY NOTE
!! For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.

!! Custom antibodies beyond the list can be tailored flexibly. Please directly Email us your specific demands.

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For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.

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